Suppression of carrageenan-induced hyperalgesia, hyperthermia and edema by a bradykinin antagonist.

European Journal of Pharmacology
Ann Costello, K Hargreaves

Abstract

Although bradykinin (BK) antagonists have antinociceptive effects, they have not been evaluated for anti-inflammatory activity. When administered with carrageenan into the rat hindpaw, NPC567 significantly blocked carrageenan-induced hyperalgesia, hyperthermia and edema. In addition, NPC567 did not alter the in vitro release of immunoreactive BK by plasma kallikrein. These results indicate that the antinociceptive activity of NPC567, a BK antagonist, may be related to its overall anti-inflammatory activity and that is mechanism of action does not include inhibition of plasma kallikrein.

References

May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L R SterankaS H Snyder
Dec 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·E T WhalleyR J Vavrek
Apr 14, 1987·European Journal of Pharmacology·L R SterankaS H Snyder
Aug 1, 1985·Pathology, Research and Practice·B Heymer

❮ Previous
Next ❯

Citations

Jul 1, 1991·Agents and Actions·M G HenriquesJ B Calixto
Jan 28, 1992·European Journal of Pharmacology·J Damas, G Remacle-Volon
Nov 1, 1992·Pharmacology & Therapeutics·J M Hall
Dec 5, 1996·European Journal of Pharmacology·R O De CamposJ B Calixto
Jan 9, 1999·European Journal of Pharmacology·T S SalehJ B Calixto
Oct 1, 1994·British Journal of Clinical Pharmacology·K P O'KaneP J Vallance
Mar 1, 1991·British Journal of Pharmacology·F J HockJ Knolle
Mar 1, 1991·British Journal of Pharmacology·K WirthJ Knolle
Jul 1, 1992·British Journal of Pharmacology·M G HenriquesT J Williams
Nov 1, 1993·British Journal of Pharmacology·S H FerreiraS Poole
Feb 28, 2002·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yoshitaka Hirayama, Hiroshi Kayakiri
Jul 23, 2011·The European Journal of Neuroscience·Phoebe E ScotlandArmen N Akopian
Feb 8, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·F C AmendoeiraH C Castro-Faria-Neto
Oct 1, 1992·Kidney International·I Gavras
Feb 13, 2007·Memórias do Instituto Oswaldo Cruz·Valber da Silva FrutuosoHugo C Castro-Faria-Neto
Jan 17, 2009·Memórias do Instituto Oswaldo Cruz·L C GuenkaR O Beleboni
Oct 1, 1993·Pain·Hans-Georg Schaible, Blair D Grubb
Oct 7, 2000·Journal of Dental Research·H E GoodisK M Hargreaves
Jun 21, 2012·Molecular Pain·Dimitris N XanthosJürgen Sandkühler
Jan 31, 2018·Biomolecules & Therapeutics·Seung-In Choi, Sun Wook Hwang
Sep 9, 2010·Anesthesiology·De-Yong LiangJ David Clark
Jan 1, 1996·Peptides·J Damas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.