Suppression of cocaine relapse-like behaviors upon pimavanserin and lorcaserin co-administration.

Neuropharmacology
Noelle C AnastasioKathryn A Cunningham

Abstract

Cocaine use disorder (CUD) is a major public health challenge for which there are no pharmacotherapeutics approved by the United States Food and Drug Administration (FDA). The propensity to relapse in CUD involves several vulnerability factors including sensitivity to cues associated with cocaine-taking. Serotonin (5-hydroxytryptamine, 5-HT) neurotransmission, particularly through the 5-HT2A receptor (5-HT2AR) and 5-HT2C receptor (5-HT2CR), is mechanistically linked to cocaine-seeking in preclinical models. In the present experiments, we employed self-administration assays in male rats to investigate whether acute and/or repeated administration of the FDA-approved selective 5-HT2AR antagonist/inverse agonist pimavanserin, selective 5-HT2CR agonist lorcaserin or their combination would alter cocaine intake and/or cocaine-seeking behavior. We found that acute administration of lorcaserin, but not pimavanserin, attenuated cocaine intake while pimavanserin plus lorcaserin did not impact cocaine self-administration. In contrast, 10-days of repeated administration of pimavanserin, lorcaserin, or pimavanserin plus lorcaserin during forced abstinence from cocaine self-administration, blunted cocaine-seeking, similar to the acute admini...Continue Reading

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Citations

Aug 26, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S Stevens Negus, Matthew L Banks
Jan 4, 2021·Addiction Biology·Caroline A AroutMargaret Haney
Apr 17, 2021·Neuropharmacology·Katherine M SerafineEric P Zorrilla
Aug 31, 2021·Pharmacology, Biochemistry, and Behavior·S S Negus, M L Banks
Aug 30, 2021·Neuropharmacology·I E Cisneros, K A Cunningham
Oct 3, 2020·Neuropharmacology·Giuseppe Di Giovanni, Philippe De Deurwaerdère

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