Suppression of Con A-induced hepatitis induction in ICOS-deficient mice

Immunology Letters
Shiho WatanabeRyo Abe

Abstract

Although there is growing evidence that NKT cells play an important role in various immune responses through the invariant T cell receptor, other cell surface molecules responsible for their function are not fully understood. Here we study the role of ICOS, the third member of the CD28 family of costimulatory receptors, in in vivo and in vitro NKT cell responses. To establish its in vivo role in systems dependent on NKT cells, we examined the development of Con A-induced hepatitis in ICOS knockout (ICOS(-/-)) mice. We demonstrated that hepatic injury in ICOS(-/-) mice was greatly suppressed as evidenced by the reduced elevation of serum transaminases, reduced apoptosis of hepatocytes and mild histopathological changes. In investigating the cause of this defect, we first found that the NKT cell population is significantly reduced in the liver and spleen of ICOS(-/-) mice. We made and analyzed mixed bone marrow chimera mice with bone marrow cells from ICOS(+/+) and ICOS(-/-) mice, and demonstrated that the defect in ICOS-mediated costimulation results in a significant defect in the development of NKT cells, especially of Valpha14i NKT cells, in the thymus. When we examined the function of residual NKT cells in ICOS(-/-) mice, we ...Continue Reading

References

Jul 1, 1992·The Journal of Clinical Investigation·G TiegsA Wendel
Jan 1, 1996·Annual Review of Immunology·D J LenschowJ A Bluestone
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K TsuneyamaY Nakanuma
Dec 23, 1999·International Immunology·T TamataniN Hanzawa-Higuchi
Jan 5, 2000·Nature·S K YoshinagaG Senaldi
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·V LingM Collins
May 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·K TakedaK Okumura
May 12, 2000·Immunological Reviews·T AboH Watanabe
Sep 7, 2000·The Journal of Experimental Medicine·J L MatsudaM Kronenberg
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A J McAdamG J Freeman
Nov 30, 2000·Immunology Today·D I GodfreyA G Baxter
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y HayakawaK Okumura
Feb 13, 2002·Hybridoma and Hybridomics·S SakamotoT Tamatani
Mar 26, 2002·Nature Reviews. Immunology·Arlene H Sharpe, Gordon J Freeman
Jan 25, 2003·Annual Review of Immunology·Masaru TaniguchiHiroshi Wakao
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claire ForestierAlbert Bendelac
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Honglin XuChyung-Ru Wang
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dass S VinayByoung S Kwon
Jan 5, 2005·Biochemical and Biophysical Research Communications·Hiroshi KanedaKo Okumura
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yeonseok ChungChen Dong
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Omid AkbariRosemarie H DeKruyff

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Citations

Jan 1, 2014·Human Immunology·Avadhesh Kumar SinghSatya N Das
Nov 23, 2010·Trends in Molecular Medicine·Marianne J van den HeuvelS M Mansour Haeryfar
Sep 10, 2014·Biochemical and Biophysical Research Communications·Young Rae JiZae Young Ryoo
Feb 9, 2010·Nature Immunology·Dale I GodfreyAlan G Baxter
Apr 20, 2019·International Journal of Molecular Sciences·Aaron OchelKatrin Neumann

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