Suppression of cryptococcosis and histoplasmosis by ketoconazole in athymic nude mice

The Journal of Infectious Diseases
D M WilliamsH B Levine

Abstract

Congenitally athymic nude (nu/nu) mice are more susceptible to disseminated cryptococcosis and histoplasmosis than their heterozygous (nu/ + ) thymus-bearing litter-mates. The therapeutic efficacy of ketoconazole, an orally absorbable antifungal agent, was evaluated in nu/nu and nu/ + mice infected intraperitoneally with Cryptococcus neoformans and Histoplasma capsulatum. Two- to five-week courses of ketoconazole significantly prolonged the survival of nu/nu mice infected with either fungus in dose-dependent fashion, but death eventually followed discontinuance of therapy. More significant protection was seen in nu/ + mice infected with C. neoformans, and markedly lower fungal counts in organs, with some negative cultures, were seen in ketoconazole-treated nu/ + mice infected with H. capsulatum. These studies indicate that ketoconazole is effective against both fungi, although results of treatment are much better in the immunologically intact nu/ + host.

Citations

Jan 1, 1987·Diagnostic Microbiology and Infectious Disease·W H Beggs, C E Hughes
Jan 1, 1984·Sabouraudia·J R Graybill, J Ahrens
Jun 1, 1985·Sabouraudia·J R Graybill, J Ahrens
Jan 1, 1992·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·T J WalshJ R Graybill
Jul 1, 1981·Antimicrobial Agents and Chemotherapy·I J Sud, D S Feingold
Jun 1, 1982·Antimicrobial Agents and Chemotherapy·M L ShigematsuT Arai
Sep 1, 1982·Infection·B A DijkmansJ W van der Meer
Aug 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T J Walsh, A Pizzo
Jul 27, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan HeeresPaul Lewi
Sep 29, 2006·Antimicrobial Agents and Chemotherapy·Lisa F ShubitzLeonard Katz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.