PMID: 11927261Apr 3, 2002Paper

Suppression of DNA-mediated charge transport by BamHI binding

Chemistry & Biology
Kazuhiko NakataniIsao Saito

Abstract

A guanine radical cation produced by one-electron DNA oxidation migrates over long distances through the DNA pi-stack. Fundamental questions regarding the likelihood of charge transport in genomic DNA, the effects of protein binding, and its biological consequences arise as the next issues of study. Electronic effects of protein binding on the efficiency of charge transport were investigated for the endonuclease BamHI-DNA complex. Direct contact of a positively charged guanidium group of BamHI to guanines in the recognition sequence 5'-GGATCC-3' completely suppressed one-electron oxidation of the guanine in the protein binding site and dramatically lowered the charge transport efficiency through the sequence. Electronically insulated guanines, by the hydrogen bonding contact of a guanidium group in BamHI, no longer function as a stepping stone in the charge transport through the DNA pi-stack.

References

Aug 22, 1996·Nature·D B HallJ K Barton
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·J JortnerM E Michel-Beyerle
Sep 20, 2000·Accounts of Chemical Research·B Giese
Mar 27, 2001·Accounts of Chemical Research·F D LewisM R Wasielewski
Jul 18, 2001·Journal of the American Chemical Society·H A WagenknechtJ K Barton
Oct 17, 2001·Biochemistry·M E NúñezJ K Barton
Oct 25, 2001·The Journal of Organic Chemistry·Kazuhiko NakataniIsao Saito
Feb 19, 2002·Chemical Reviews·Cynthia J. Burrows, James G. Muller

❮ Previous
Next ❯

Citations

Nov 5, 2002·Current Opinion in Chemical Biology·Bernd Giese
Mar 11, 2010·Chemical Reviews·Joseph C Genereux, Jacqueline K Barton
Jan 6, 2010·Journal of the American Chemical Society·Joseph C GenereuxJacqueline K Barton
Oct 25, 2003·Nucleic Acids Research·J R MilliganJ F Ward
Apr 6, 2006·Nucleic Acids Research·Chad C Bjorklund, William B Davis
Apr 27, 2012·Journal of Biomedicine & Biotechnology·Jiyoung KangMasaru Tateno
Sep 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tadao TakadaTetsuro Majima
Mar 4, 2008·Current Opinion in Chemical Biology·Edward J MerinoJacqueline K Barton
Jun 7, 2008·Chemical Communications : Chem Comm·Yasuko OsakadaTetsuro Majima
Mar 11, 2011·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Yohsuke HagiwaraMasaru Tateno
May 8, 2010·Organic & Biomolecular Chemistry·Cristina ButchosaAlexander A Voityuk
Mar 10, 2011·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Yohsuke Hagiwara, Masaru Tateno
Jun 9, 2005·Chemical Reviews·Konrad SzaciłowskiGrazyna Stochel
Jan 4, 2007·Journal of the American Chemical Society·Matthew Ray HolmanSteven E Rokita
Sep 24, 2010·Journal of the American Chemical Society·Kiyohiko KawaiTetsuro Majima
Jun 28, 2019·Journal of the American Chemical Society·Huabing SunMarc M Greenberg
Sep 1, 2005·Journal of the American Chemical Society·Tadao Takada, Jacqueline K Barton
Jun 13, 2002·Journal of the American Chemical Society·Kazuhiko NakataniIsao Saito
Mar 29, 2007·The Journal of Physical Chemistry. B·Alexander A Voityuk, William B Davis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Physics. Condensed Matter : an Institute of Physics Journal
Yohsuke HagiwaraMasaru Tateno
Journal of the American Chemical Society
Gail S BlausteinAlexander L Burin
© 2022 Meta ULC. All rights reserved