Suppression of drug-resistant Staphylococcal Infections by the quorum-sensing inhibitor RNAIII-inhibiting peptide

The Journal of Infectious Diseases
Giorgio Dell'AcquaNaomi Balaban

Abstract

Staphylococcus aureus and S. epidermidis are major causes of infection related to biofilm formed on indwelling medical devices. Such infections are common causes of morbidity and mortality and, because of biofilm resistance to antibiotics, are difficult to treat. The RNAIII-inhibiting peptide (RIP) (YSPWTNF-NH2) inhibits the pathogenesis of staphylococci by disrupting bacterial cell-cell communication (known as "quorum sensing"). Using a vascular-graft rat model, we show that RIP, applied locally and systemically, can completely inhibit drug-resistant S. aureus and S. epidermidis biofilms. The present study provides the first direct demonstration that interfering with cell-cell communication by use of a quorum-sensing inhibitor can eliminate medical device-associated staphylococcal infections. We suggest that medical devices could be coated with RIP to prevent infections, including those by antibiotic-resistant staphylococcal strains.

Citations

Oct 31, 2006·Analytical and Bioanalytical Chemistry·Niamh HarraghyMathias Herrmann
Jun 23, 2010·Seminars in Plastic Surgery·Robert C Fang, Robert D Galiano
Jul 21, 2010·Planta medica·Cassandra L QuaveBradley C Bennett
Feb 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stan Deresinski
Jan 14, 2005·Current Opinion in Infectious Diseases·Barbara W TrautnerRabih O Darouiche
Jan 14, 2011·Plastic and Reconstructive Surgery·Nalini RaoBenjamin A Lipsky
Mar 21, 2007·Antimicrobial Agents and Chemotherapy·Naomi BalabanGiorgio Scalise
Jun 6, 2007·Infection and Immunity·Laura H TsangMark S Smeltzer
Dec 2, 2008·Critical Care : the Official Journal of the Critical Care Forum·Shadaba Asad, Steven M Opal
Mar 29, 2013·Future Microbiology·Garry LavertyBrendan F Gilmore
Nov 13, 2012·Biotechnology Advances·Vipin Chandra Kalia
Apr 29, 2011·Veterinary Immunology and Immunopathology·Gabriel LeitnerNaomi Balaban
Oct 29, 2008·Medicinal Research Reviews·Nanting NiBinghe Wang
Jul 4, 2006·Advances in Chronic Kidney Disease·Gino Tapia, Jerry Yee
Dec 21, 2005·Biomaterials·Davide CampocciaCarla Renata Arciola
Mar 14, 2012·FEMS Immunology and Medical Microbiology·Deirdre Fitzgerald-HughesHilary Humphreys
Oct 2, 2007·Journal of Vascular Surgery·Isabelle JaverliatJean-Louis Gaillard
Nov 3, 2006·The Journal of Bone and Joint Surgery. American Volume·William A JiranekA Seth Greenwald
Feb 4, 2009·Current Opinion in Urology·John D Denstedt, Peter A Cadieux
Jan 30, 2015·Critical Reviews in Food Science and Nutrition·Venkidasamy BaskarShivraj Hariram Nile
Sep 8, 2009·Expert Opinion on Therapeutic Patents·Jiachuan Pan, Dacheng Ren
Aug 2, 2005·Clinical Orthopaedics and Related Research·Naomi BalabanGiorgio Dell'Acqua
Oct 6, 2007·The International Journal of Artificial Organs·Y QiuX Wen
Oct 17, 2008·The International Journal of Artificial Organs·M D KiranN Balaban
Apr 13, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Hozan MuftyInge Fourneau

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