Suppression of experimental antigen-induced arthritis in transgenic mice producing human alpha-fetoprotein

Biochemical and Biophysical Research Communications
A OgataS Nishi

Abstract

Experimental arthritis was induced in the knee joint of transgenic mice expressing human alpha-fetoprotein by immunization with methylated bovine serum albumin in Freund's complete adjuvant. In the control experiment with normal C57BL/6 mice, definite arthritis was observed in 55.6% (5/9) of the mice, but in only 21.1% (4/19) of the transgenic mice. This result suggested that human alpha-fetoprotein functioned as an immunosuppressant to ameliorate the development of the immune disease.

Citations

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Jan 27, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Patrizia CarliniGiuseppe Rotilio
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