Abstract
The ability of activated T lymphocytes to penetrate the extracellular matrix and migrate to target tissues was found to be related to expression of a heparanase enzyme (Naparstek, Y., I. R. Cohen, Z. Fuks, and I. Vlodavsky. 1984. Nature (Lond.). 310:241-243; Savion, N., Z. Fuks, and I. Vlodavsky. 1984. J. Cell. Physiol. 118:169-176; Fridman, R., O. Lider, Y. Naparstek, Z. Fuks, I. Vlodavsky, and I. R. Cohen. 1987. J. Cell. Physiol. 130:85-92; Lider, O., J. Mekori, I. Vlodavsky, E. Baharav, Y. Naparstek, and I. R. Cohen, manuscript submitted for publication). We found previously that heparin molecules inhibited expression of T lymphocyte heparanase activity in vitro and in vivo, and administration of a low dose of heparin in mice inhibited lymphocyte traffic and delayed-type hypersensitivity reactions (Lider, O., J. Mekori, I. Vlodavsky, E. Baharav, Y. Naparstek, and I. R. Cohen, manuscript submitted for publication). We now report that treatment with commercial or chemically modified heparins at relatively low doses once daily (5 micrograms for mice and 20 micrograms for rats) led to inhibition of allograft rejection and the experimental autoimmune diseases adjuvant arthritis and experimental autoimmune encephalomyelitis. Highe...Continue Reading
References
May 5, 1978·Science·R L Edwards, F R Rickles
Jan 1, 1987·Journal of Cellular Physiology·R FridmanI R Cohen
Jul 1, 1987·Arthritis and Rheumatism·R StanescuI R Cohen
Jun 10, 1986·Journal of Immunological Methods·E BaharavI R Cohen
Aug 1, 1985·Arthritis and Rheumatism·I R CohenA Frenkel
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·W van EdenI R Cohen
Jun 3, 1967·Nature·S Sasaki
Aug 1, 1972·Archives of Neurology·E Chelmicka-Szorc, B G Arnason
Jul 19, 1984·Nature·Y NaparstekI Vlodavsky
Jan 7, 1983·Science·J HoloshitzI R Cohen
Nov 1, 1983·Transplantation·B KimS A Rosenberg
Feb 1, 1984·Journal of Cellular Physiology·N SavionZ Fuks
Nov 1, 1983·Cellular Immunology·M S SyB Benacerraf
Feb 1, 1964·Arthritis and Rheumatism·C M PEARSON
Citations
Sep 1, 1995·Journal of Cellular Physiology·H Q MiaoI Vlodavsky
Feb 1, 1991·Journal of Neuroscience Research·W F HickeyH Kimura
Apr 1, 1991·Diabetologia·P SaïM Ouary
Nov 1, 1994·Agents and Actions·A Ialenti, M Di Rosa
Oct 1, 1991·Journal of the Neurological Sciences·L BøS Mørk
Apr 15, 1995·Thrombosis Research·A WunderW Maier-Borst
Sep 1, 1991·Immunology Letters·G Korczak-KowalskaA Górski
May 1, 1991·Immunology Letters·A GórskiT Glapiński
Apr 1, 1992·Journal of Neuroimmunology·P A LudowykC R Parish
Oct 1, 1993·Immunology Today·N S IhrckeJ L Platt
Dec 14, 2002·Journal of the Neurological Sciences·Michal Irony-Tur-SinaiTalma Brenner
Apr 30, 1998·Journal of the Neurological Sciences·D SchwartzT Brenner
Jun 24, 1998·Transplantation Proceedings·K TeranishiR C Robbins
Jun 24, 1998·Transplantation Proceedings·K TeranishiR C Robbins
Jun 24, 1998·Transplantation Proceedings·K TeranishiR C Robbins
Mar 20, 1999·Transplantation Proceedings·K TeranishiR C Robbins
Dec 2, 1999·Journal of Hepatology·R HershkovizZ Halpern
May 12, 2001·Burns : Journal of the International Society for Burn Injuries·M J Saliba
Jan 8, 2000·Dermatologic Clinics·A S Boyd
Nov 19, 2002·Clinics in Dermatology·Ronni WolfBinnur Tüzün
Dec 1, 1991·Current Opinion in Immunology·A MillerH L Weiner
Oct 1, 1994·Immunology and Cell Biology·M R BartlettC R Parish
Oct 17, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Matti WatermanNeta Ilan
Aug 19, 2006·Nature Reviews. Immunology·Christopher R Parish
Oct 19, 2001·British Journal of Pharmacology·A SmailbegovicC P Page
Nov 9, 2000·Alimentary Pharmacology & Therapeutics·A PapaG Gasbarrini
Sep 21, 2001·Alimentary Pharmacology & Therapeutics·I DotanZ Halpern
Mar 14, 1998·Immunology·M S DouglasJ A Kirby
Apr 29, 1998·Immunology and Cell Biology·C R ParishD O Willenborg
Sep 21, 2001·Immunology and Cell Biology·E J HindmarshC R Parish
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·O LiderI R Cohen
Jan 1, 1996·AIDS Research and Human Retroviruses·P ClayetteD Dormont
Nov 24, 1998·Transplantation·B A YardF J van der Woude
Jul 31, 2001·Transplantation·C BraunF J van der Woude
Sep 28, 2002·Transplantation·Rafael Fernandez-BotranJohn H Barker
Jul 1, 1997·Inflammatory Bowel Diseases·J R Korzenik
Jan 1, 1995·American Journal of Reproductive Immunology : AJRI·L D ErmelW H Kutteh
Jun 22, 1999·American Journal of Reproductive Immunology : AJRI·A CadavidA Beer
Jan 1, 1991·Brain Pathology·W F Hickey
Jan 1, 1991·Brain Pathology·H WekerleR Meyermann
Oct 1, 1995·Gut·A D DwarakanathJ M Rhodes
Jun 15, 2005·Annual Review of Biochemistry·T M HandelA E Proudfoot
Dec 31, 2005·Blood·Evgeny EdovitskyMichael Elkin
Oct 12, 2000·Biochemical and Biophysical Research Communications·E McKenzieM Page
May 9, 2014·Metabolic Brain Disease·Norah G VerboutHalina Offner
Dec 24, 1997·Transplant Immunology·M S DouglasJ A Kirby
Feb 15, 2012·Cellular and Molecular Life Sciences : CMLS·Esther HermanoMichael Elkin
Jan 1, 1991·Free Radical Research Communications·Y Oyanagui, S Sato
Jan 1, 1990·Free Radical Research Communications·Y Oyanagui, S Sato
Nov 11, 2010·Expert Opinion on Therapeutic Targets·Ioannis MitroulisKonstantinos Ritis