Suppression of experimental autoimmune myasthenia gravis by nasal administration of acetylcholine receptor

Journal of Neuroimmunology
C G MaH Link

Abstract

Experimental autoimmune myasthenia gravis (EAMG) is a well established animal model, which can be induced in various animal species and strains with acetylcholine receptor (AChR) and represents an experimental counterpart of human myasthenia gravis (MG). Current immunotherapies of both EAMG and MG are non-specific and limited by their toxicity. Tolerance to EAMG has been achieved by oral administration of milligram quantities of Torpedo AChR. In the present report we demonstrate that nasal administration of microgram doses of Torpedo AChR to female Lewis rats prior to immunization with Torpedo AChR and complete Freund's adjuvant resulted in the prevention of subsequently induced EAMG, the suppression of serum anti-AChR antibody levels, the decrease of delayed-type hypersensitivity responses to AChR, as well as the suppression of AChR-specific immunoglobulin G-secreting cells, AChR-reactive interferon-gamma-secreting cells and T cell proliferation in peripheral lymphoid organs, particularly in popliteal and inguinal lymph nodes regional to immunization. We conclude that clinical signs of EAMG can be efficiently prevented by nasal administration of AChR in parallel with the downregulation of both B and T cell responses specific t...Continue Reading

References

Apr 1, 1978·The Journal of Experimental Medicine·V A LennonR Ulevitch
Jun 1, 1990·Immunological Reviews·H M Dintzis, R Z Dintzis
Jun 1, 1991·The Journal of Clinical Investigation·H LinkT Olsson
Jan 1, 1988·Annals of the New York Academy of Sciences·D B DrachmanC Kahn
Jun 1, 1993·Immunology Today·J F Bach

❮ Previous
Next ❯

Citations

Dec 4, 1998·Springer Seminars in Immunopathology·H L Weiner, Y Komagata
Dec 13, 1997·Molecular Neurobiology·J Lindstrom
Nov 25, 2000·Journal of the American College of Cardiology·Y WangN R Rose
Dec 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·X F Bai, H Link
Aug 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael Sela, Edna Mozes
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D Daniel, D R Wegmann
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·D BarchanS Fuchs
Aug 1, 1996·The Journal of Experimental Medicine·G X ZhangT Olsson
Jul 21, 1998·Annals of the New York Academy of Sciences·J LindstromM Nelson
Jul 21, 1998·Annals of the New York Academy of Sciences·S Ragheb, R P Lisak
Jan 1, 1997·Annual Review of Medicine·H L Weiner
Dec 22, 1999·The Journal of Clinical Investigation·H L Weiner
Aug 17, 2011·Therapeutics and Clinical Risk Management·Sivakumar Sathasivam
Jul 21, 1998·Annals of the New York Academy of Sciences·C AntozziR Mantegazza
May 4, 2010·Annals of Neurology·Jie LuoJon M Lindstrom
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Leana WenPatricia C Giclas
Jul 29, 2015·Biochemical Pharmacology·Jie Luo, Jon Lindstrom
Mar 20, 2010·Autoimmunity·M C SouroujonS Fuchs
Jul 11, 2012·Expert Opinion on Pharmacotherapy·Jordi Díaz-ManeraIsabel Illa
Jul 16, 2005·Expert Opinion on Biological Therapy·Sonia Berrih-AkninMiriam C Souroujon
Jan 19, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P ChristadossC Deng
Nov 5, 1997·Clinical Immunology and Immunopathology·B G Xiao, H Link
Mar 15, 2000·Muscle & Nerve·J M Lindstrom

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.