PMID: 7446746Dec 1, 1980

Suppression of gastric acid secretion by furosemide in isolated gastric mucosa of guinea pig

The American Journal of Physiology
A AyalonS R Caplan

Abstract

The effect of furosemide on acid secretion and Cl- transport was studied in isolated fundic mucosa of the guinea pig. Furosemide (10(-3) M), applied to the serosal side produced an immediate effect on the short-circuit current (Isc), lowering it by 47 +/- 2%. Potential difference decreased by 29 +/- 3%, electrical conductance by 18 +/- 4%, acid secretion by 38 +/- 1%, and net flux of Cl- from serosal-to-mucosal side by 37%. Application of the drug to the mucosal side produced similar effects on acid secretion and on the electrical parameters. It is suggested that furosemide blocks the entrance of Cl-, by the Na+--Cl- cotransport mechanism, through the basolateral membrane of the secreting cell. The consequent reduction in electrogenic Cl- transport would cause Isc and acid secretion to decrease. A reduction of Cl- conductance of the apical membrane, upon mucosal application of the drug, would cause similar effects on acid secretion and Cl- transport.

Citations

Nov 6, 2009·American Journal of Physiology. Cell Physiology·Sascha KopicJohn P Geibel
Aug 9, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Philipp KirchhoffJohn P Geibel
May 23, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H XueJ X Zhu
Aug 12, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nichole McDanielChristian Lytle

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