Nov 12, 1977

Suppression of gonadotrophin release in many by an inhibitory analogue of L.H.-releasing hormone

D Gonzalez-BarcenaA V Schally


The ability of an inhibitory analogue of L.H.-releasing hormone (L.H.R.H.) to suppress the release of luteinising hormone (L.H.) and follicle-stimulating hormone (F.S.H.) after administration of a small does of L.H.R.H. was tested in four men. A single intramuscular injection of 90 mg (D-Phe-2,D-Trp-3,D-Phe-6)-L.H.R.H. diminished the gonadotrophin response to 25 micrometer of L.H.R.H. given 1, 4, 8, and 24 hours afterwards. Basal levels of L.H. and F.S.H. were not lowered. The results demonstrate that an inhibitory analogue of L.H.R.H. is active in man and suggest the possibility that inhibitors of L.H.R.H. might eventually form the basis of a new method of birth control.

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Mentioned in this Paper

Visual Suppression
Follicle Stimulating Hormone
Gonadotropins Measurement
Serum LH Measurement
Metabolic Suppression
Gonadorelin Hydrochloride
Luteinizing Hormone

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