Suppression of gonadotropin secretion by a long-acting gonadotropin-releasing hormone analog (leuprolide acetate, Lupron Depot) in children with precocious puberty

The Journal of Clinical Endocrinology and Metabolism
M KappyR Clemons

Abstract

The GnRH analog leuprolide acetate has been shown to be effective in the treatment of precocious puberty when given as a daily sc injection. We studied the effectiveness of a single im dose of a new depot form of leuprolide in suppressing estradiol and gonadotropin secretion in children with precocity. Five girls with previously untreated precocity showed significant decreases in basal serum estradiol and FSH levels and in peak LH levels (after GnRH testing) 30 days after a single im dose of leuprolide acetate for depot suspension. Mean peak FSH levels also fell greatly, but the difference was not significant. No adverse effects were noted during the first 4-6 months of monthly im injections. Depot im leuprolide appears to be effective in suppressing estradiol and gonadotropin secretion, and may be a useful method of treating children with central precocious puberty.

Citations

Aug 14, 2003·The Journal of Pediatrics·Paul Saenger, Marielisa Rincon
Mar 5, 2002·Clinical Endocrinology·Carl-Joachim PartschWolfgang G Sippell
Jan 20, 1991·The New England Journal of Medicine·P M Conn, W F Crowley
Aug 5, 2005·Environmental Health Perspectives·Frederick S vom Saal, Claude Hughes
Sep 2, 2004·Paediatric Drugs·Franco Antoniazzi, Giorgio Zamboni
Feb 18, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Karen KleinFernando Cassorla
Oct 7, 2008·Animal Reproduction Science·Atunga NyachieoThomas M D'Hooghe
Jun 1, 2017·Current Opinion in Pediatrics·Ximena LopezUNKNOWN Pediatric Endocrine Society Transgender Health Special Interest Group
Dec 1, 2018·Nature Reviews. Drug Discovery·Aaron C AnselmoSamir Mitragotri
Jan 2, 1995·American Journal of Medical Genetics·A N DerenoncourtK L Jones
Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Jean-Claude CarelJean Louis Chaussain
Sep 2, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·C J PartschW G Sippell
Dec 17, 2005·Arquivos brasileiros de endocrinologia e metabologia·Ana Luísa AguiarLuís Fernando Adan
Apr 23, 2017·Scientific Reports·Mika KiyoharaKazuyoshi Tsutsui
Sep 15, 2000·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·D R ReillyR W Hudson
Sep 25, 2009·Journal of Pediatric Endocrinology & Metabolism : JPEM·Daniela CohenKaren O Klein
Feb 24, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A V Schally
Mar 3, 2021·Nature Communications·Natasha C BrighamMatthew L Becker

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