PMID: 7539726Jun 1, 1995Paper

Suppression of haematopoiesis by IgG autoantibodies from patients with systemic lupus erythematosus (SLE)

Clinical and Experimental Immunology
H LiuS Saito

Abstract

The inhibiting activity of serum on haematopoiesis has been described in patients with SLE. To explore further the features of serum inhibitor, we first examined the suppression of granulocytic and erythroid colony formation in vitro by serum from patients with SLE using methylcellulose culture. The potent inhibiting activity was demonstrated in six of 20 patients. All of these six patients were associated with leukocytopenia and/or anaemia. Five of 10 sera from patients with active SLE suppressed the colony formation of both burst-forming units of erythrocyte (BFU-E) and colony-forming units of granulocyte/macrophage (CFU-GM), and one serum suppressed BFU-E only. IgG fraction isolated from sera with inhibiting activity suppressed colony formation without complement involvement. The elimination of monocytes and lymphocytes from target mononuclear cells did not affect the suppression by the IgG fractions. The suppressive effect was completely eliminated after incubation of the IgG fractions with progenitor-enriched mononuclear cells. Flow cytometric analysis showed these IgG bound to CD34+ haematopoietic progenitor cells, but not to CD33+ cells. These data suggest that (i) the inhibitor of colony formation in serum was observed ...Continue Reading

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Citations

Feb 26, 2000·British Journal of Haematology·B Bader-MeunierG Tchernia
Aug 3, 2002·Leukemia & Lymphoma·Helen A PapadakiGeorge D Eliopoulos
Jul 1, 1997·The Journal of International Medical Research·Y MorishitaT Horie
May 13, 2009·Nature Reviews. Rheumatology·Peter E Westerweel, Marianne C Verhaar
May 1, 2007·Arthritis and Rheumatism·Peter E WesterweelMarianne C Verhaar
Feb 9, 2019·Journal, Genetic Engineering & Biotechnology·Hala Zaki RaslanMahitab El-Kassaby
May 9, 2001·Leukemia & Lymphoma·E KissG Szegedi
Nov 25, 2004·Hematology·Nancy BerlinerThomas P Loughran
Aug 15, 2012·Acta Haematologica·Jan LakotaMartin Stern
Sep 29, 2011·Nature Reviews. Rheumatology·Mariana J Kaplan
Jun 1, 2003·Modern Rheumatology·Yoko TabushiHiroshi Hashimoto
Aug 22, 2021·BMJ Case Reports·Bhoobalan MagendiranChanaveerappa Bammigatti

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