PMID: 9652857Jul 4, 1998Paper

Suppression of heat-induced HSF activation by CDDP in human glioblastoma cells

International Journal of Radiation Oncology, Biology, Physics
H MatsumotoE Kano

Abstract

The kinetics of the accumulation of inducible 72-kD heat shock protein (hsp72) and the activation of heat shock transcriptional factor (HSF) after hyperthermia and/or CDDP treatment in two human glioblastoma cell lines, A-172 having the wild-type p53 gene and T98G having the mutated p53 gene were evaluated. Western blot analysis of hsp72, gel-mobility shift assay of HSF, cell survival, and development of thermotolerance were examined. The prominent suppression of heat-induced hsp72 accumulation by CDDP was seen in A-172 cells, but not in T98G cells. This was due to the p53-dependent inhibition of heat-induced HSF activation by CDDP. The interactive hyperthermic enhancement of CDDP cytotoxicity was observed in A-172 cells, but not in T98G cells. In addition, the heat-induced thermotolerance was suppressed by the presence of CDDP in the pretreatment. Suppression of heat-induced hsp72 accumulation by CDDP contributes to an interactive hyperthermic enhancement of CDDP cytotoxicity in the cells bearing the wild-type p53 gene.

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Citations

May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Norihiko NaritaHitoshi Saito
Aug 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S At-AssaC Lambre
Jun 9, 2004·International Journal of Radiation Oncology, Biology, Physics·Zhao-Hui JinEiichi Kano
Apr 12, 2003·Pflügers Archiv : European journal of physiology·Hua ZhouAkira Hishida
Jun 24, 2000·International Journal of Radiation Biology·T OhnishiH Matsumoto
May 3, 2013·International Journal of Molecular Medicine·Yoshiaki Tabuchi, Takashi Kondo

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