PMID: 8588059Jul 1, 1995Paper

Suppression of HPA-axis activity by haloperidol after experimentally induced heat stress

Progress in Neuro-psychopharmacology & Biological Psychiatry
J HennigP Netter

Abstract

1. Healthy male volunteers were exposed to either a heat condition (52 degrees C) or normal temperature (28 degrees C) receiving a single oral dose of 3 mg haloperidol or placebo in a double-blind design. 2. Ratings on aversiveness as well as on intensity of ambient temperature and saliva samples for determination of cortisol were sampled at defined intervals. Body core temperature and sweat loss were measured continuously throughout the three hour experiment. 3. Results indicate increased levels of cortisol after exposure to heat but not after a pretreatment with haloperidol. 4. The findings of this study suggest that D2-receptors of tuberoinfundibular neurons are blocked by haloperidol which suppresses the dopamine mediated release of vasopressin induced by dehydration and the subsequent stimulation of CRH.

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Citations

Jan 14, 2000·Psychoneuroendocrinology·J HennigP Netter
Mar 22, 2001·British Journal of Clinical Pharmacology·S J de VisserJ M van Gerven
Jan 27, 2006·The American Journal of Chinese Medicine·Yen-Ying KungShinn-Jang Hwang
Dec 3, 1999·European Journal of Biochemistry·A MoraF Centeno

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