PMID: 8592635Sep 29, 1995Paper

Suppression of immune function by non-peptidic delta opioid receptor antagonists

Neuroscience Letters
R V HouseH N Bhargava

Abstract

Previous studies in this laboratory and elsewhere have provided evidence that compounds acting as delta opioid receptor agonists exhibit marked immunostimulatory potential. Conversely, the delta opioid receptor antagonists have previously been shown to demonstrate immunosuppressive effects as assessed by proliferation of T-cells following allogeneic or xenogeneic stimulation. The present study was performed to further characterize this immunosuppressive activity using the compounds benzylidene naltrexone (BNTX), naltrindole (NTI), and naltriben (NTB). In vitro exposure to BNTX resulted in an apparent dose-related suppression of B-cell proliferation, cytokine production by T-helper cells, and natural killer (NK) cell activity, with statistically significant suppression observed at concentrations between 1 and 10 microM. NTI was also immunosuppressive for all immune function parameters examined, although this compound was less active than BNTX. In vitro exposure to the structurally related compound NTB had no significant effect on any immune function examined in this study. In all cases, immunosuppression occurred in the absence of any detectable alteration in cellular viability, suggesting a specific immunosuppressive effect rat...Continue Reading

References

Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D D TaubT J Rogers
Feb 1, 1994·Immunopharmacology and Immunotoxicology·R V HouseH N Bhargava
Feb 1, 1993·Transplantation Proceedings·K ArakawaH Nagase

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Citations

Aug 17, 2005·International Immunopharmacology·Mark R Hutchinson, Andrew A Somogyi
Apr 23, 2004·Life Sciences·Antonella D'AmbrosioFrancesca Quintieri
Apr 29, 1998·Trends in Pharmacological Sciences·S D BryantL H Lazarus
Jan 1, 1996·Peptides·G A OlsonA J Kastin
Jul 11, 2006·Journal of Medicinal Chemistry·Qiang ZhangWilliam J Welsh
Apr 28, 2012·The Journal of Pharmacology and Experimental Therapeutics·Jyoti Joshi MundraRichard D Howells
Aug 9, 2007·Brain Research Bulletin·Eniko IojaSándor Benyhe
Mar 7, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tsung-Chih TsengShiang-Jong Tzeng

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