PMID: 266731May 1, 1977Paper

Suppression of immunoglobulin synthesis and secretion by peripheral blood lymphocytes from normal donors

Proceedings of the National Academy of Sciences of the United States of America
S A SchwartzY S Choi

Abstract

Concanavalin A (Con A)-treated peripheral blood lymphocytes from healthy volunteer donors have been shown to suppress proliferative responses associated with thymus-derived lymphocytes (T-cells). The present investigations demonstrate that peripheral blood lymphocytes incubated with Con A for 48 hr can abrogate pokeweed mitogen-stimulated differentiation of bone-marrow-derived (B) lymphocytes to immunoglobulin-synthesizing and -secreting plasma cells. This effect was manifested when washed Con A-treated peripheral blood lymphocytes were added to pokeweed mitogen-stimulated cocultures containing fresh autologous or allogeneic mononuclear cells, and it did not appear to involve cytotoxicity. Parallel control cultures consisting of mononuclear leukocytes incubated for 48 hr in the absence of Con A also had immunoglobulin suppressor activity in mixing experiments. This effect, however, was most pronounced when preincubated cells were added to fresh autologous pokeweed mitogen-stimulated peripheral blood lymphocytes. Cell mixtures containing peripheral blood lymphocytes demonstrated a spectrum of immunoregulatory effects ranging from suppression to enhancement of pokeweed mitogen-stimulated immunoglobulin synthesis and secretion. Se...Continue Reading

References

Jan 1, 1975·Transplantation Reviews·A Nisonoff, S A Bangasser
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Citations

Sep 1, 1979·Head & Neck Surgery·H J Wanebo
Dec 1, 1979·Journal of Surgical Oncology·L P SvederskyJ P Minton
Apr 1, 1983·Digestive Diseases and Sciences·M G MutchnickA L Goldstein
Jan 1, 1981·Springer Seminars in Immunopathology·D Y Leung, R S Geha
Jul 1, 1979·The American Journal of Medicine·A KapadiaN K Day
Jan 1, 1981·International Journal of Immunopharmacology·C L BergerR L Edelson
Dec 7, 1978·The New England Journal of Medicine·S Broder, T A Waldmann
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L ShouC L Chen
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E G EnglemanR Goldsby
May 1, 1979·Cellular Immunology·S PahwaR A Good
Jun 1, 1982·Clinical Immunology and Immunopathology·M G MutchnickF E Weller
Jan 1, 1979·Immunological Reviews·F D Finkelman, P E Lipsky
Sep 1, 1987·American Journal of Hematology·M P NairS A Schwartz

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