PMID: 9443666Jan 27, 1998Paper

Suppression of infectious virus spread and corneal opacification by the combined use of recombinant interferon beta and interleukin-10 following corneal infection with herpes simplex virus-1 in mice

Antiviral Research
H MinagawaR Mori

Abstract

The effects of Interleukin-10 (IL-10) and recombinant murine interferon-beta (rMuIFN-beta) on experimental corneal herpes simplex virus 1 (HSV-1) inoculation in BALB/c mice were examined. The mice were inoculated with the HSV-1 strain KOS at their corneas after abrasion. IL-10 was then administered topically once a day for 10 days beginning 2 days post inoculation, while rMuIFN-beta was administered once a day for 10 days beginning 1 day post inoculation. The local viral growth in the inoculated eyes and trigeminal ganglia was reduced in the rMuIFN-beta-treated mice but not in the IL-10-treated mice. In the mice treated with both rMuIFN-beta and IL-10, the degree of both the local viral growth and corneal opacification decreased. The establishment of HSV-1 latency in the trigeminal ganglia was partially prevented by rMuIFN-beta treatment but not by IL-10 treatment. The combined use of the cytokines resulted in both the suppression of viral spread and the prevention of corneal inflammation induced by HSV-1 infection.

References

Jul 1, 1991·The Journal of General Virology·R L HendricksJ C Glorioso
Jul 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J OphirM Revel
Jan 1, 1994·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Y SakaiR Mori
Dec 1, 1993·European Heart Journal·M R Visser, G M Vercellotti

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Citations

Jun 28, 2011·PloS One·Sharon Ka-Wai LeeChi-Pui Pang
Nov 21, 2012·Ocular Immunology and Inflammation·Hassan GhasemiSoghrat Faghihzadeh
Mar 21, 1998·The Journal of Experimental Medicine·K GoldsmithR L Hendricks
Feb 11, 2004·The Journal of General Virology·Hiroko MinagawaYusuke Yanagi
May 12, 2017·Journal of Virology·Dhong Hyun Lee, Homayon Ghiasi
Dec 23, 2006·Journal of Leukocyte Biology·Andrew J LepistoRobert L Hendricks
May 3, 2014·Journal of Virology·Hongmin YunRobert L Hendricks
Jan 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregory M FrankRobert L Hendricks
Aug 14, 2020·Investigative Ophthalmology & Visual Science·Adrian FilibertiDaniel J J Carr

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