Suppression of Inflammation and Arthritis by Orally Administrated Cardiotoxin from Naja naja atra

Evidence-based Complementary and Alternative Medicine : ECAM
Cao-Xin ChenZheng-Hong Qin

Abstract

Cardiotoxin (CTX) from Naja naja atra venom (NNAV) reportedly had analgesic effect in animal models but its role in inflammation and arthritis was unknown. In this study, we investigated the analgesic, anti-inflammatory, and antiarthritic actions of orally administered CTX-IV isolated from NNAV on rodent models of inflammation and adjuvant arthritis. CTX had significant anti-inflammatory effects in models of egg white induced nonspecific inflammation, filter paper induced rat granuloma formation, and capillary osmosis tests. CTX significantly reduced the swelling of paw induced by egg white, the inflammatory exudation, and the formation of granulomas. CTX reduced the swelling of paw, the AA clinical scores, and pathological alterations of joint. CTX significantly decreased the number of the CD4 T cells and inhibited the expression of relevant proinflammatory cytokines IL-17 and IL-6. CTX significantly inhibited the secretion of proinflammatory cytokine IL-6 and reduced the level of p-STAT3 in FLS. These results suggest that CTX inhibits inflammation and inflammatory pain and adjuvant-induced arthritis. CTX may be a novel therapeutic drug for treatment of arthritis.

References

Sep 11, 1975·The New England Journal of Medicine·J A Van Boxel, S A Paget
Jan 1, 1973·Arthritis and Rheumatism·L KourounakisM A Kupusta
Oct 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·R GiorgiY Cury
Nov 1, 1995·Toxicon : Official Journal of the International Society on Toxinology·X C PuP Gopalakrishnakone
May 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·R Stevens-Truss, C L Hinman
Dec 22, 1999·Clinical and Experimental Immunology·R M GoodfellowB P Morgan
Jun 28, 2002·Cleveland Clinic Journal of Medicine·Matthew R Weir
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ekkehard MayJoel D Taurog
Apr 19, 2005·Arthritis Research & Therapy·Vivianne MalmströmLars Klareskog
May 12, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Adam MorMichael H Pillinger
May 19, 2005·Arthritis Research & Therapy·Jan LeipeHendrik Schulze-Koops
Oct 18, 2005·Current Opinion in Immunology·Ulrich Walter, Pere Santamaria
Mar 17, 2006·Acta Pharmacologica Sinica·Zhi-Xin ChenZheng-Hong Qin
Jan 1, 1936·Proceedings of the National Academy of Sciences of the United States of America·D I Macht
Jul 22, 2006·Toxicon : Official Journal of the International Society on Toxinology·Hui-Ling ZhangZheng-Hong Qin
Mar 22, 2007·Nature Immunology·Estelle BettelliVijay K Kuchroo
Apr 29, 2008·Journal of Molecular Recognition : JMR·Dexian DongRongxiu Li
May 6, 2008·Best Practice & Research. Clinical Rheumatology·Claire L Gorman, Andrew P Cope
Aug 30, 2008·Blood·Jinfang Zhu, William E Paul
Sep 4, 2008·Toxicon : Official Journal of the International Society on Toxinology·Wei-jian JiangShu-jin Zhao
Nov 5, 2008·The Journal of Clinical Investigation·Fionula M Brennan, Iain B McInnes
Jan 10, 2009·Annual Review of Immunology·Thomas KornVijay K Kuchroo
Jan 27, 2009·Acta Pharmacologica Sinica·Yan-Li LiuZheng-Hong Qin
Apr 18, 2009·Microbes and Infection·Pierre Miossec
Sep 24, 2009·Current Rheumatology Reports·Sarah L Gaffen
Oct 3, 2009·Science·Ashutosh ChaudhryAlexander Y Rudensky
Oct 3, 2009·Nature Reviews. Rheumatology·Wim B van den Berg, Pierre Miossec
Oct 15, 2009·Toxicon : Official Journal of the International Society on Toxinology·Antony GomesAparna Gomes
Dec 17, 2009·Cell Research·Jinfang Zhu, William E Paul
Mar 3, 2010·Immunological Reviews·Beatrix Bartok, Gary S Firestein
Mar 16, 2011·The Journal of Biological Chemistry·Shivaprasad H VenkateshaKamal D Moudgil
Mar 31, 2011·Toxicon : Official Journal of the International Society on Toxinology·Cho Yeow Koh, R Manjunatha Kini
May 18, 2011·Toxicon : Official Journal of the International Society on Toxinology·Li-Wen ChenLong-Sen Chang
Feb 24, 2012·Clinical Pharmacology and Therapeutics·Inés ColmegnaHenri A Menard
May 30, 2012·The American Journal of Pathology·Mohan S MaddurJagadeesh Bayry
Nov 14, 2012·Nature Reviews. Rheumatology·Nunzio Bottini, Gary S Firestein
Apr 18, 2013·Asian Pacific Journal of Tropical Biomedicine·Vivek Kumar VyasUtsav Parmar

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Software Mentioned

SPSS

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here