Suppression of interleukin-6 production in macrophages by furonaphthoquinone NFD-37

International Immunopharmacology
Hyun-Mo ShinYoungsoo Kim

Abstract

Furonaphthoquinone compounds have been reported to exhibit anticancer, antibacterial and antiviral properties. The molecular basis for these diverse properties is not known. 2-Methyl-2-(2-methylpropenyl)-2,3-dihydronaphthoquinone [2,3-b]furan-4,9-dione (NFD-37) is a synthetic furonaphthoquinone compound. In the present study, NFD-37 was found to inhibit interleukin (IL)-6 production in lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7. Further, NFD-37 attenuated LPS-induced synthesis of IL-6 transcript but also inhibited LPS-induced IL-6 promoter activity. Since nuclear factor (NF)-kappaB activation has been shown to play a key role in LPS-induced IL-6 expression, the effect of NFD-37 on LPS-induced NF-kappaB activation was further analyzed. NFD-37 exhibited a dose-dependent inhibitory effect on LPS-induced phosphorylation of inhibitory kappaB alpha protein (IkappaB alpha), and subsequently inhibited LPS-induced IkappaB alpha degradation as well as NF-kappaB transcriptional activity. In another experiment, NFD-37 inhibited both IL-6 promoter activity and NF-kappaB transcriptional activity elicited by an expression vector encoding IkappaB kinase beta. Taken together, NFD-37 down-regulated LPS-induced IL-6 expressi...Continue Reading

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Citations

Mar 20, 2009·Natural Product Research·T G RodriguesJ M Sforcin
Aug 8, 2009·Natural Product Research·J M SforcinJ K Bastos
Mar 26, 2015·International Journal of Molecular Sciences·You-Ren ChenCherng-Chyi Tzeng
Mar 17, 2012·The Journal of Pharmacy and Pharmacology·Tatiana Fernanda BachiegaJosé Maurício Sforcin
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Aug 31, 2011·Molecular and Cellular Biochemistry·Eduardo Luis BizettoSilvia Maria Suter Correia Cadena

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