PMID: 6976412Jan 1, 1982Paper

Suppression of interstitial nephritis by auto-anti-idiotypic immunity

The Journal of Experimental Medicine
E G Neilson, M Phillips

Abstract

Rats immunized with renal tubular antigens were protected from the development of interstitial nephritis by pretreatment with tubular antigen-reactive T lymphoblasts. Protected animals developed anti-idiotypic antibodies against idiotypes primarily within the antigen-binding region of monoclonal antitubular basement membrane antibodies. These studies extend the concept of auto-anti-idiotypic regulation to autoimmune disease, and they also provide an experimental basis for further efforts to develop biologically relevant mechanisms for attenuating the expression of other kidney diseases.

References

Jan 1, 1978·Annual Review of Medicine·R T McCluskey, R B Colvin
Aug 1, 1978·European Journal of Immunology·M J BosmaJ L Owen
Jan 1, 1980·Journal of Immunological Methods·J M Davie
Jul 1, 1980·Molecular Immunology·M I GreeneB Benacerraf
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P M FloodH Schreiber

❮ Previous
Next ❯

Citations

Jan 1, 1982·Springer Seminars in Immunopathology·P R Carnegie, I R Mackay
Sep 1, 1982·Indian Journal of Pediatrics·A K Abbas
Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Nov 1, 1986·Journal of Reproductive Immunology·L LustigB Denduchis
Jan 1, 1989·Research in Immunology·F RossiM D Kazatchkine
Sep 1, 1988·Journal of the American Academy of Dermatology·M J Rico, R P Hall
Jun 1, 1991·Scandinavian Journal of Immunology·T Bricio, F Mampaso
Jun 21, 1993·Annals of the New York Academy of Sciences·D B DrachmanL Balcer
Jul 1, 1988·Postgraduate Medical Journal·I R Mackay, M J Rowley
May 1, 1986·Immunological Investigations·M Zanetti
Jun 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M Zanetti, C B Wilson
Mar 1, 1991·Kidney International·C B Wilson
Mar 1, 1991·Kidney International·C J KellyC M Meyers
May 1, 1989·Kidney International·E G Neilson
Nov 1, 1989·Clinical Immunology and Immunopathology·U E NydeggerM D Kazatchkine
Jan 1, 1983·Annals of the New York Academy of Sciences·M Zanetti
Jan 1, 1986·Annals of the New York Academy of Sciences·P E Bigazzi
Jan 1, 1988·Annals of the New York Academy of Sciences·D B DrachmanC Kahn
Jan 1, 1993·Renal Failure·F MeeusP Druet
May 12, 2017·Journal of Immunology Research·Darel MartínezAna María Hernández
Jun 1, 1986·Arthritis and Rheumatism·D M Klinman, A D Steinberg
Aug 1, 1986·Kidney International·E G NeilsonR Mann
Sep 1, 1983·Kidney International·E G Neilson, B Zakheim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.