PMID: 7537636Apr 21, 1995Paper

Suppression of intestinal neoplasia by DNA hypomethylation

Cell
P W LairdR Jaenisch

Abstract

We have used a combination of genetics and pharmacology to assess the effects of reduced DNA methyltransferase activity on ApcMin-induced intestinal neoplasia in mice. A reduction in the DNA methyltransferase activity in Min mice due to heterozygosity of the DNA methyltransferase gene, in conjunction with a weekly dose of the DNA methyltransferase inhibitor 5-aza-deoxycytidine, reduced the average number of intestinal adenomas from 113 in the control mice to only 2 polyps in the treated heterozygotes. Hence, DNA methyltransferase activity contributes substantially to tumor development in this mouse model of intestinal neoplasia. Our results argue against an oncogenic effect of DNA hypomethylation. Moreover, they are consistent with a role for DNA methyltransferase in the generation of the C to T transitions seen at high frequency in human colorectal tumors.

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y MiyoshiG Petersen
Dec 24, 1992·Cell·J C ShenP A Jones
Sep 17, 1992·Nature·S M PowellK W Kinzler
Jan 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P A JonesY C Tsai
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R F BoyntonS J Meltzer
Nov 1, 1991·Journal of Toxicology and Environmental Health·R L Vorce, J I Goodman
Nov 22, 1991·Science·R A Weinberg
Aug 11, 1991·Nucleic Acids Research·P W LairdA Berns
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W S el-DeiryS B Baylin
Mar 23, 1990·Cell·J Tazi, A Bird
Jan 1, 1990·Advances in Cancer Research·P A Jones, J D Buckley
Jan 1, 1990·Advances in Cancer Research·H J ScrableW K Cavenee
Dec 1, 1989·Mutation Research·T C Brown, M L Brown-Luedi
Apr 11, 1989·Nucleic Acids Research·J PósfaiR J Roberts
Apr 1, 1986·Bioscience Reports·M EhrlichC W Gehrke
Jul 20, 1987·Journal of Molecular Biology·M Gardiner-Garden, M Frommer
Jan 1, 1982·CRC Critical Reviews in Biochemistry·R L Adams, R H Burdon
Feb 28, 1983·Biochemical and Biophysical Research Communications·A P Feinberg, B Vogelstein
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D V SantiC E Garrett
Oct 11, 1983·Nucleic Acids Research·M A Gama-SosaM Ehrlich
Jun 30, 1982·Biochimica Et Biophysica Acta·R Y WangM Ehrlich
Dec 1, 1993·Molecular and Cellular Biology·S U KassR L Adams
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·F Antequera, A Bird
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·R JüttermannR Jaenisch
Jan 1, 1993·Mutation Research·R Holliday, G W Grigg
Jan 1, 1994·Human Molecular Genetics·P W Laird, R Jaenisch

❮ Previous
Next ❯

Citations

Jan 17, 1996·International Journal of Cancer. Journal International Du Cancer·M E DudleyD C Roopenian
Mar 29, 2000·Journal of Cellular Physiology·R L Momparler, V Bovenzi
Jul 21, 1998·Genes, Chromosomes & Cancer·S PedemonteL Varesco
Sep 1, 2000·Journal of Cellular Biochemistry·M VairapandiN J Duker
Nov 1, 1996·Genes, Chromosomes & Cancer·C Luongo, W F Dove
Jul 19, 2002·The Journal of Gene Medicine·Andrew SlackMoshe Szyf
Sep 25, 2001·The Journal of Pathology·A M JubbP Quirke
Dec 7, 2007·Cell and Tissue Research·Tom LathamBernard Ramsahoye
Sep 1, 2007·Hepatology International·Motohisa TadaOsamu Yokosuka
Dec 1, 1995·Toxicology Letters·J L Counts, J I Goodman
May 12, 2005·Critical Reviews in Oncology/hematology·Werner Digel, Michael Lübbert
Aug 1, 1998·Mutation Research·S Venkatachalam, L A Donehower
Sep 1, 1997·Cancer Genetics and Cytogenetics·J BernardinoB Dutrillaux
Jun 30, 2001·Trends in Pharmacological Sciences·M Szyf
Mar 6, 1998·Trends in Biotechnology·M ZhangR Sager
Jul 27, 2002·Trends in Genetics : TIG·Michael A Goldman
Mar 24, 2000·Trends in Genetics : TIG·S B Baylin, J G Herman
Feb 5, 2003·Cancer Letters·Kenneth P Nephew, Tim Hui-Ming Huang
May 22, 2002·Biochimica Et Biophysica Acta·Michaela Herzig, Gerhard Christofori
Jun 5, 2003·Biochimica Et Biophysica Acta·Rachel H GilesHans Clevers
Jun 7, 1997·Biochimica Et Biophysica Acta·P Polakis
Aug 8, 1997·Biochimica Et Biophysica Acta·R Mostoslavsky, Y Bergman
Nov 13, 2004·The Journal of Nutritional Biochemistry·Y I Kim
Jul 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H H MüllerZ Dobbie
Aug 17, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M IlyasW F Bodmer
Mar 11, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M IlyasW F Bodmer
Sep 1, 1995·Current Biology : CB·A Balmain
Dec 10, 1999·Critical Reviews in Oncology/hematology·J P Issa
Oct 30, 1998·Journal of the American Society for Mass Spectrometry·J S KlassenE R Williams
Aug 23, 2002·Seminars in Cancer Biology·John R Melki, Susan J Clark
Sep 12, 2001·The International Journal of Biochemistry & Cell Biology·M FranchinaP H Kay
May 1, 1997·Molecular Medicine Today·P W Laird
Mar 21, 2002·The Lancet Oncology·P R SrinivasS Srivastava
Aug 23, 2001·Trends in Molecular Medicine·R Fodde, R Smits

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.