PMID: 8945508Nov 29, 1996Paper

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

Cell
M OshimaM M Taketo

Abstract

Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H2: constitutive COX-1 and inducible COX-2. To assess the role of COX-2 in colorectal tumorigenisis, we determined the effects of COX-2 gene (Ptgs2) knockouts and a novel COX-2 inhibitor on Apc delta716 knockout mice, a model of human familial adenomatous polyposis. A Ptgs2 null mutation reduced the number and size of the intestinal polyps dramatically. Furthermore, treating Apc delta716 mice with a novel COX-2 inhibitor reduced the polyp number more significantly than with sulindac, which inhibits both isoenzymes. These results provide direct genetic evidence that COX-2 plays a key role in tumorigenesis and indicate that COX-2-selective inhibitors can be a novel class of therapeutic agents for colorectal polyposis and cancer.

Associated Clinical Trials

Dec 28, 2007·Sharon Spencer, MD,, Sharon Spencer, MD,

References

Sep 17, 1992·Nature·S M PowellK W Kinzler
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R F BoyntonS J Meltzer
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M K O'BanionD A Young
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D L DeWitt, W L Smith
Apr 21, 1995·Cell·P W LairdR Jaenisch
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·M OshimaM Taketo
Jan 20, 1994·Nature·J Vane
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A MitchellJ R Vane
Sep 13, 1993·FEBS Letters·G P O'Neill, A W Ford-Hutchinson
May 6, 1993·The New England Journal of Medicine·F M GiardielloG J Offerhaus
Apr 1, 1996·Gastroenterology·R N DuBoisA J Entingh
Oct 1, 1996·Gastroenterology·C S WilliamsR N DuBois

❮ Previous
Next ❯

Citations

Dec 17, 1997·International Journal of Cancer. Journal International Du Cancer·P RicchiA M Acquaviva
Jul 27, 1999·International Journal of Cancer. Journal International Du Cancer·K Müller-DeckerG Fürstenberger
Oct 3, 1999·International Journal of Cancer. Journal International Du Cancer·H BambaF Matsuzaki
Apr 14, 2000·Pharmazie in unserer Zeit·G Dannhardt, L Hahn
Feb 27, 2001·Journal of Surgical Oncology·K UefujiH Mochizuki
Nov 18, 2000·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·M Osiri, L W Moreland
Jan 22, 2000·Arthritis and Rheumatism·L J CroffordL B van de Putte
Feb 24, 2001·BioFactors·K WatanabeK Wakabayashi
Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·Nikolaos G NikitakisJohn J Sauk
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Douglas J E ElderChristos Paraskeva
Jul 19, 2002·International Journal of Cancer. Journal International Du Cancer·Caroline KamateDidier Fradelizi
Apr 17, 2001·International Journal of Cancer. Journal International Du Cancer·H K RoyA Ratashak
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·N KunduA M Fulton
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·H Vainio
Nov 16, 2002·The Journal of Pathology·Douglas J E ElderChristos Paraskeva
Feb 19, 2000·Biochemical and Biophysical Research Communications·A WächtershäuserJ Stein
Feb 13, 2001·Biochemical and Biophysical Research Communications·M AtharD R Bickers
Jun 9, 2001·Biochemical and Biophysical Research Communications·C LavagnaP Rampal
Nov 9, 2000·Cellular Immunology·C A EisengartJ M Daly
Apr 29, 1998·Diseases of the Colon and Rectum·A Banerjee, P Quirke
Dec 22, 1999·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·T KoshibaM Imamura
Mar 4, 2005·Archives of Pharmacal Research·Young-Joon Surh, Joydeb Kumar Kundu
Jul 13, 2000·European Journal of Drug Metabolism and Pharmacokinetics·H Vainio, G Morgan
Feb 18, 2003·European Journal of Drug Metabolism and Pharmacokinetics·Y S R KrishnaiahP Bhaskar
May 14, 2005·Cancer Immunology, Immunotherapy : CII·Namita KunduAmy M Fulton
Mar 11, 2008·Cancer Immunology, Immunotherapy : CII·Yunyun SuElieser Gorelik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.