PMID: 9433911Jan 20, 1998Paper

Suppression of intracellular hydrogen peroxide generation and catalase levels in CD8+ T-lymphocytes from HIV+ individuals

Free Radical Biology & Medicine
S YanoS J Kim

Abstract

CD8+ T-lymphocytes from HIV+ individuals contain short telomeres, a sign of cell senescence. To test our hypothesis that the cell type is functionally defective in the biochemical indices related to cell proliferation, we investigated the profiles of intracellularly generated H2O2 levels with or without PMA as well as immunoreactive catalase levels using flow cytometric method. We observed that, in HIV+ but not in HIV- individuals, the constitutively generated H2O2 level was significantly lower in CD8+ T-cells compared with CD4+ T-cells. Importantly, activated effector CD8+CD28- cells showed remarkably low H2O2 levels compared with CD8+CD28+ cells, and the latter in HIV+ individuals also showed low levels. A similar defect of CD8+ cells of HIV+ individuals was also seen with H2O2 levels stimulated with PMA in the presence of a catalase inhibitor. Furthermore, the immunoreactive catalase content was lower in CD8+ cells compared with CD4+ cells only in HIV+ individuals. These results suggest that CD8+ T-lymphocytes are functionally defective with the constitutively generated and PMA-elicited levels of H2O2 and the corresponding scavenger. Diminished immunocompetence of HIV+ individuals may be caused, in part, by the functional de...Continue Reading

References

Nov 25, 1992·Journal of Immunological Methods·A R RosenkranzG J Zlabinger
Jul 1, 1992·International Journal of Immunopharmacology·H RabesandratanaJ Dornand
Apr 18, 1991·Nature·E H Blackburn
Aug 1, 1991·Experimental Cell Research·J C ReedG J Fisher
Jan 1, 1989·Free Radical Biology & Medicine·L W OberleyD Kasemset-St Clair
Jun 30, 1986·Biochemical and Biophysical Research Communications·M TsujimotoG Weissmann
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·F J StaalL A Herzenberg
Jan 1, 1995·Immunologic Research·D F Tough, J Sprent
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·S HaldarC M Croce
Jan 1, 1993·Cytometry·H Rabesandratana, J Dornand
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S L ChurchJ M Trent

❮ Previous
Next ❯

Citations

Jun 19, 2001·Trends in Neurosciences·V MollaceC F Perno
Jun 18, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Sarah JansenPeter L Kaye
Dec 23, 2008·Journal of Neuroimmunology·Ixane VelázquezLoyda M Meléndez
Mar 11, 2006·Clinical Science·Tongguang WangAvindra Nath

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.