Suppression of isoprenaline-induced increase in plasma renin concentration by vasoconstrictors in rats with nonfunctioning Macula densa.

Naunyn-Schmiedeberg's Archives of Pharmacology
D K MeyerC Mittermayer

Abstract

The mechanism of the increase in plasma renin concentration caused by the beta-sympathomimetic agent isoprenaline has been further investigated. Rats were pretreated by occluding the left renal artery for 2 hrs, thus rendering the macula densa cells of this kidney nonfunctioning. After contralateral nephrectomy infusion of isoprenaline (1.5 mug/kg min) still caused a strong increase in plasma renin concentration. This increase was significantly suppressed by simultaneous infusion of angiotensin II (1.0 mug/kg min). The alpha-sympathomimetic amine phenylephrine (60 mug/kg min) or octapressin (10 mU/kg min). The results exclude any mediator-role of the macula densa receptors in the isoprenaline-induced release of renin. The possibility of a stimulation of renin release via the baroreceptors or a direct "secretomotoric" action of isoprenaline is discussed.

References

Apr 5, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·J Greven
Feb 1, 1974·The American Journal of Physiology·R VandongenG W Boyd
Sep 1, 1974·The American Journal of Physiology·W AoiM H Weinberger
Feb 1, 1973·Circulation Research·R VandongenG W Boyd
Jul 1, 1967·Physiological Reviews·A J Vander

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Citations

Aug 1, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·H BollG Hertting
Jun 27, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·D K Meyer, M Herrmann

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