Suppression of Laser-Induced Choroidal Neovascularization by the Oral Medicine Targeting Histamine Receptor H4 in Mice

Translational Vision Science & Technology
Ryo IjimaHiroko Terasaki

Abstract

This study aimed to examine relationship of histamine receptor H4 (HRH4) and the pathogenesis of laser-induced choroidal neovascularization (laser-CNV) and to determine whether oral administration of HRH4 antagonists suppressed laser-CNV in mice. Laser photocoagulation was performed in mice to induce the laser-CNV. Histamine was administered intravitreously, and CNV volume was measured. Laser photocoagulation and intravitreous injection of HRH4 antagonist JNJ7777120 were performed after intraperitoneal injection of clodronate liposome, which depletes circulating monocyte-derived macrophages; CNV volume was compared with that in mice injected with control (dimethyl sulfoxide [DMSO]/PBS). Three days after laser-CNV, the F4/80(+)CD11b(+) macrophage population in retinal pigment epithelium (RPE)/choroid complex was quantified with flow cytometry in wild-type and Hrh4(-/-) mice. The long-acting HRH4 antagonist JNJ28307474 was then administrated periorally, and the laser-CNV volume was compared with controls. Intravitreous injection of histamine did not affect laser-CNV volume. The laser-CNV from the eye injected with JNJ7777120 was equivalent to that injected with the DMSO/PBS in mice that had intraperitoneally received clodronate l...Continue Reading

References

Jun 8, 2001·Biochemical and Biophysical Research Communications·F CogéJ P Galizzi
Sep 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Florian GantnerKevin B Bacon
May 15, 2003·Survey of Ophthalmology·Jayakrishna AmbatiAnthony P Adamis
Jul 29, 2003·Investigative Ophthalmology & Visual Science·Eiji SakuraiJayakrishna Ambati
Jul 29, 2003·Investigative Ophthalmology & Visual Science·Diego G Espinosa-HeidmannScott W Cousins
Jan 15, 2004·The Journal of Pharmacology and Experimental Therapeutics·Robin L ThurmondLars Karlsson
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takashi NakayamaOsamu Yoshie
Dec 31, 2004·The New England Journal of Medicine·Evangelos S GragoudasUNKNOWN VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group
Oct 6, 2006·The New England Journal of Medicine·Philip J RosenfeldUNKNOWN MARINA Study Group
Oct 6, 2006·The New England Journal of Medicine·David M BrownUNKNOWN ANCHOR Study Group
Oct 6, 2006·The New England Journal of Medicine·Paulus T V M de Jong
May 18, 2007·The Journal of Allergy and Clinical Immunology·Dorothea DijkstraRalf Gutzmer
Dec 7, 2007·Investigative Ophthalmology & Visual Science·Takayuki NagaiAkira Negi
Mar 28, 2008·Nature·Mark E KleinmanJayakrishna Ambati
May 20, 2008·Investigative Ophthalmology & Visual Science·Hiroki KanekoHiroko Terasaki
Nov 26, 2008·Lancet·Hanna R ColemanEmily Y Chew
Mar 25, 2009·British Journal of Pharmacology·E Zampeli, E Tiligada
May 6, 2009·British Journal of Pharmacology·W M ConnellyP L Chazot
Jun 16, 2009·Nature·Atsunobu TakedaJayakrishna Ambati
Nov 13, 2009·The Journal of Investigative Dermatology·Jeffery M CowdenRobin L Thurmond
Sep 3, 2010·The Journal of Clinical Investigation·Alan C Bird
Nov 6, 2010·Investigative Ophthalmology & Visual Science·Keiko KataokaHiroko Terasaki
Jul 17, 2012·Neuron·Jayakrishna Ambati, Benjamin J Fowler
Mar 16, 2013·British Journal of Pharmacology·K KarlstedtP Panula
Mar 28, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jeffery M CowdenRobin L Thurmond
May 25, 2013·Nature Reviews. Immunology·Jayakrishna AmbatiBradley D Gelfand
Nov 16, 2013·Investigative Ophthalmology & Visual Science·Tina RistauSascha Fauser
May 6, 2014·Investigative Ophthalmology & Visual Science·Mohammad Hosein Nowroozzadeh
May 6, 2014·Investigative Ophthalmology & Visual Science·Tina Ristau, Sascha Fauser
Sep 23, 2014·Investigative Ophthalmology & Visual Science·Ryo IjimaHiroko Terasaki

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Citations

Sep 18, 2018·Ophthalmic Surgery, Lasers & Imaging Retina·Gloria Paulina Trujillo-SanchezAndrew C Weitz
Sep 15, 2020·Investigative Ophthalmology & Visual Science·Hideyuki ShimizuHiroki Kaneko

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