Suppression of leptin-induced hypothalamic JAK/STAT signalling and feeding response during pregnancy in the mouse

Reproduction : the Official Journal of the Society for the Study of Fertility
S R LadymanD R Grattan

Abstract

Hyperphagia during pregnancy, despite rising concentrations of the satiety hormone leptin, suggests that a state of leptin resistance develops. This study investigated the satiety response and hypothalamic responses to leptin during pregnancy in the mouse. Pregnant (day 13) and nonpregnant mice received an i.p. injection of either leptin or vehicle and then 24-h food intake was measured. Further groups of pregnant and nonpregnant mice were perfused 2 h after leptin or vehicle injections and brains were processed for pSTAT3 and pSTAT5 immunohistochemistry. Leptin treatment significantly decreased food intake in nonpregnant mice. In pregnant mice, however, leptin treatment did not suppress food intake, indicating a state of leptin resistance. In the arcuate nucleus, leptin treatment increased the number of cells positive for pSTAT3, a marker of leptin activity, to a similar degree in both nonpregnant and pregnant mice. In the ventromedial nucleus (VMN), the leptin-induced increase in pSTAT3-positive cell number was significantly reduced in pregnant mice compared to that in nonpregnant mice. In nonpregnant mice, leptin treatment had no effect on the number of pSTAT5-positive cells, suggesting that in this animal model, leptin does...Continue Reading

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Citations

Jun 26, 2014·Brain Sciences·Phyllis E Mann
Dec 10, 2013·Neuroscience·V S NagaishiJ Donato
Jun 24, 2015·The Journal of Endocrinology·David R Grattan
Mar 1, 2015·The Journal of Nutritional Biochemistry·Licai ChengXu-Feng Huang
Sep 24, 2013·JAK-STAT·Sharon R Ladyman, David R Grattan
Sep 24, 2013·JAK-STAT·Celine S NicolasStephane Peineau
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Oct 27, 2016·Journal of Neuroendocrinology·S R Ladyman, D R Grattan
Feb 26, 2019·Journal of Neuroendocrinology·Rachael A AugustineSharon R Ladyman
Apr 17, 2018·Endocrinology·Sharon Rachel LadymanDavid Ross Grattan
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