PMID: 6978837May 1, 1982Paper

Suppression of lymphocyte activation by a protein released from isolated perfused rat liver

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
C PizzoF V Chisari

Abstract

Isolated rat liver perfusates contain a substance which inhibits 3H-thymidine uptake by phytohemagglutinin-stimulated human peripheral blood lymphocytes in a dose-dependent, noncytotoxic fashion. Suppression is not due to interference of lymphocyte-phytohemagglutinin interaction or dilution of the thymidine pool. Complete inhibition of thymidine uptake is achieved with less than 1.0 microgram of material per ml (which is a potentially achievable concentration in vivo). The release of this material is directly and quantitatively associated with hepatocellular injury as measured by release of glutamic pyruvate transaminase. The material is a highly basic protein with a molecular weight of approximately 65,000 to 80,000 daltons. It is a product of the hepatocyte rather than of nonparenchymal liver cells. Liver-derived materials, such as the presently described molecule, may play a role in in situ regulation of lymphocyte function during immunologically mediated liver disease.

References

Oct 29, 1979·Biochemical and Biophysical Research Communications·B VossK von Figura
Oct 1, 1974·The Journal of Experimental Medicine·F V Chisari, T S Edgington
Oct 18, 1974·Nature·K SchumacherU Wehmer
Apr 1, 1981·Springer Seminars in Immunopathology·G A Levy, F V Chisari

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Citations

Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F V ChisariG G Leroux-Roels
Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S P TzungS A Cohen
Feb 1, 1986·Australian and New Zealand Journal of Medicine·M MackinnonR A Smallwood
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S P TzungS A Cohen
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W GrauerP A Berg
Aug 24, 2021·Frontiers in Immunology·Ian BaudiMasanori Isogawa

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