PMID: 12783791Jun 5, 2003Paper

Suppression of macho-1-directed muscle fate by FGF and BMP is required for formation of posterior endoderm in ascidian embryos

Development
Keisuke KondohH Nishida

Abstract

Specification of germ layers is a crucial event in early embryogenesis. In embryos of the ascidian, Halocynthia roretzi, endoderm cells originate from two distinct lineages in the vegetal hemisphere. Cell dissociation experiments suggest that cell interactions are required for posterior endoderm formation, which has hitherto been thought to be solely regulated by localized egg cytoplasmic factors. Without cell interaction, every descendant of posterior-vegetal blastomeres, including endoderm precursors, assumed muscle fate. Cell interactions are required for suppression of muscle fate and thereby promote endoderm differentiation in the posterior endoderm precursors. The cell interactions take place at the 16- to 32-cell stage. Inhibition of cell signaling by FGF receptor and MEK inhibitor also supported the requirement of cell interactions. Consistently, FGF was a potent signaling molecule, whose signaling is transduced by MEK-MAPK. By contrast, such cell interactions are not required for formation of the anterior endoderm. Our results suggest that another redundant signaling molecule is also involved in the posterior endoderm formation, which is likely to be mediated by BMP. Suppression of the function of macho-1, a muscle det...Continue Reading

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Citations

Dec 22, 2005·Development Genes and Evolution·Yoriko NakamuraHiroki Nishida
Dec 17, 2004·Biology of the Cell·Christian SardetFrançois Prodon
Feb 7, 2012·Briefings in Functional Genomics·Yu-Bin WangJr-Kai Yu
Mar 15, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yale J Passamaneck, Anna Di Gregorio
Jun 24, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hiroki Nishida
Mar 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gaku Kumano, Hiroki Nishida
Apr 11, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christian SardetJanet Chenevert
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Hiroki Nishida
Apr 23, 2015·Pediatric Surgery International·Chen WangWei Cheng
Sep 24, 2004·Developmental Biology·Kasumi YagiYutaka Satou
Mar 10, 2015·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Yutaka Satou, Kaoru S Imai
Jun 1, 2005·Journal of Cell Science·François ProdonChristian Sardet
Sep 2, 2021·BMC Biology·Konner M WinkleyMichael T Veeman

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