Suppression of macrophage Ia antigen expression by endogenous interferon-alpha/beta

Journal of Interferon Research
T KatoS Muramatsu

Abstract

Exogenous interferon-alpha (IFN-alpha) and interferon-beta (IFN-beta) (type I IFNs) are known to suppress the IFN-gamma-dependent expression of class II MHC (Ia) antigens on macrophages (M phi). We report here that the endogenous type I IFNs produced by M phi in response to IFN inducers regulate Ia expression of the M phi themselves. Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Pretreatment of M phi with poly(I):poly(C) or a bacterial lipopolysaccharide (LPS), which is also a potent IFN inducer, in vitro or in vivo, before being exposed to IFN-gamma was also effective in suppressing the Ia expression. Such suppression was abolished by the addition of anti-IFN-alpha/beta antibodies to the M phi culture along with IFN-gamma. M phi cultured with L-cell conditioned medium (LCM) containing M-CSF were less capable of expressing Ia antigens than those cultured without LCM. The Ia-expressing ability of LCM-treated M phi was also restored by the addition of anti-IFN-alpha/beta antibodies. M phi in the early stage of sterile inflammation were less responsive to IFN-gamma than those in the late s...Continue Reading

References

Apr 1, 1986·The Journal of Experimental Medicine·K InabaS Muramatsu
Jan 15, 1981·Cellular Immunology·H B Fleit, M Rabinovitch
Jan 1, 1980·Annals of the New York Academy of Sciences·E A Havell, G L Spitalny
Sep 9, 1982·Nature·D S SnyderE R Unanue

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Citations

Jun 1, 2011·The Journal of Experimental Medicine·Erin E ZollerMichael B Jordan
May 1, 1991·Journal of the American Academy of Dermatology·K MeissnerJ Altenhoff
Nov 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M DeguchiS Muramatsu

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