Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice

The Journal of Clinical Investigation
K L BrunerKevin G Osteen

Abstract

Matrix metalloproteinases of the stromelysin family are expressed in the human endometrium as a consequence of cellular events during the menstrual cycle that require extracellular matrix remodeling. We have recently documented the presence of these enzymes in lesions of endometriosis, a benign disease that presents as persistent ectopic sites of endometrial tissue, usually within the peritoneal cavity. Endometriosis can develop after retrograde menstruation of endometrial tissue fragments, and establishment of ectopic sites within the peritoneal cavity requires breakdown of extracellular matrix. To examine whether matrix metalloproteinases might contribute to the steroid-dependent epidemiology and cellular pathophysiology of endometriosis, we have developed an experimental model of endometriosis using athymic nude mice as recipients of human endometrial tissue. Our results demonstrate that estrogen treatment of human endometrial tissue in organ culture maintains secretion of matrix metalloproteinases, and promotes establishment of ectopic peritoneal lesions when injected into recipient animals. In contrast, suppressing metalloproteinase secretion in vitro with progesterone treatment, or blocking enzyme activity with a natural ...Continue Reading

References

Nov 1, 1992·Fertility and Sterility·M D SpuijbroekJ L Evers
Jul 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L M Matrisian
Jul 1, 1991·American Journal of Obstetrics and Gynecology·T Ishimura, H Masuzaki
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D F CarmichaelG P Stricklin
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L M MatrisianR Breathnach
Jul 15, 1984·American Journal of Obstetrics and Gynecology·N M ZamahR H Kaufman
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·K L BrunerK G Osteen
Dec 1, 1994·Cell Biology International·L A Salamonsen
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·K G OsteenL M Matrisian
Jun 1, 1994·The Journal of Clinical Endocrinology and Metabolism·F SchatzC J Lockwood
May 1, 1993·Journal of Reproduction and Fertility·M MartelliP Bischof
Jan 1, 1993·American Journal of Obstetrics and Gynecology·W H RodgersF Gorstein
Jan 1, 1996·The Journal of Clinical Endocrinology and Metabolism·L S NobleS E Bulun
Aug 1, 1996·Seminars in Reproductive Endocrinology·K G OsteenK L Sharpe-Timms

❮ Previous
Next ❯

Citations

Oct 8, 2005·Angiogenesis·P G GroothuisR Grümmer
Jul 31, 2001·Fertility and Sterility·W B Nothnick
Sep 26, 2001·Fertility and Sterility·J Donnez, M Nisolle
Jan 10, 2002·Fertility and Sterility·Kathleen M EysterKeith A Hansen
Oct 10, 2002·Fertility and Sterility·Juan A Garcia-VelascoAydin Arici
Oct 10, 2002·Fertility and Sterility·David Byron Redwine
Nov 24, 1999·Fertility and Sterility·N SuzumoriK Suzumori
Dec 11, 1999·Fertility and Sterility·K M Zeitoun, S E Bulun
Jun 14, 2002·Journal of Reproductive Immunology·Serdar E BulunSijun Yang
Apr 20, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D VinatierP Dufour
Jun 28, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D VinatierP Dufour
Feb 19, 2002·The Journal of Steroid Biochemistry and Molecular Biology·S E BulunS Sebastian
Feb 1, 2000·Trends in Endocrinology and Metabolism : TEM·S E BulunH Sasano
Jan 28, 2010·Seminars in Reproductive Medicine·Kaylon L Bruner-TranKevin G Osteen
Jan 16, 2009·The New England Journal of Medicine·Serdar E Bulun
May 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Miles A MillerDouglas A Lauffenburger
Jul 28, 2009·Molecular Human Reproduction·A G Braundmeier, A T Fazleabas
Aug 19, 1999·Clinical Obstetrics and Gynecology·C A Witz
Apr 11, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W B NothnickO W Tawfik
Dec 20, 2005·Obstetrical & Gynecological Survey·Simone FerreroNicola Ragni
Apr 13, 2002·Annals of the New York Academy of Sciences·Robert M BrennerRodney W Kelly
Apr 13, 2002·Annals of the New York Academy of Sciences·Serdar E BulunSiby Sebastian
Apr 13, 2002·Annals of the New York Academy of Sciences·Kathy L Sharpe-Timms, Kathryn E Cox
Apr 13, 2002·Annals of the New York Academy of Sciences·Warren G Foster, Sanjay K Agarwal
Apr 13, 2002·Annals of the New York Academy of Sciences·Asgerally T FazleabasSerdar Bulun
Apr 13, 2002·Annals of the New York Academy of Sciences·Kathy L Sharpe-Timms
Jun 29, 2002·The Medical Journal of Australia·Kevin L Forbes
Feb 7, 2009·Reproductive Sciences·Peter A W RogersKrina T Zondervan
Nov 23, 2006·Reproductive Biology and Endocrinology : RB&E·Julie M Hastings, Asgerally T Fazleabas
Apr 16, 2009·The Journal of Clinical Endocrinology and Metabolism·Kaylon L Bruner-TranAntoni J Duleba
Jan 10, 2002·Environmental Health Perspectives·Linda S Birnbaum, Audrey M Cummings
Jan 25, 2012·International Journal of Molecular Sciences·Saumendra BajpaiCynthia A Reinhart-King
Jun 15, 2014·Reproductive Biology and Endocrinology : RB&E·Yana B AznaurovaAlex A Zhavoronkov
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Warren G Foster
Aug 27, 2014·Human Reproduction Update·Daniela GallianoAntonio Pellicer
Mar 1, 2006·Women's Health·Luigi FedeleAlessandro Bulfoni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.