PMID: 8594944Dec 1, 1995Paper

Suppression of meal size by intestinal nutrients is eliminated by celiac vagal deafferentation

The American Journal of Physiology
E K WallsTerry L Powley

Abstract

The arrival of nutrients in the gastrointestinal tract suppresses intake. To specify the neural pathways and receptor locations of this feedback, we examined the effects of intraduodenal infusions of 10 nutrients plus saline on short-term food intake of rats with selective deafferentations of vagal celiac branches. Three response profiles were observed: 1) isotonic saline, 5.6% glycerol, and 3% fructose did not inhibit intake of controls or selectively deafferented animals; 2) 3% glucose, 3% maltose, 3% L-phenylalanine, 12% Isocal, and 1.4% oleic acid suppressed intake of controls, but this inhibition was eliminated by vagal celiac deafferentation; and 3) 3% casein hydrolysate and 24% Isocal suppressed intake of controls and rats with selective vagotomies, although the latter exhibited significantly less suppression. In addition, elimination of celiac afferents chronically reduced meal size (i.e., first 30-min intake) without reducing daily food intake or body weight. Furthermore, D-phenylalanine infusions produced a delayed suppression of food intake in controls (possibly from intraluminal irritation); however, this reduction was eliminated with celiac deafferentation. Overall, this experiment indicates that vagal celiac affer...Continue Reading

Citations

Mar 11, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J E CoxS T Meller
Sep 15, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·S LalD Grundy
Dec 18, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Huiyuan ZhengHans-Rudolf Berthoud
Dec 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alan RandichJames E Cox
Aug 7, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael M ChiEdward A Fox
May 10, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mihai Covasa
Sep 11, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M CovasaG A Burns
Aug 13, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J I GlendinningH N Spain
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A RandichS S Bharaj
Apr 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S EisenG P Smith
Oct 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·G CucheC H Malbert
Mar 20, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wahiba NeftiNicolas Darcel
Sep 27, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Edward A FoxJennifer McAdams
Aug 26, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lindsey A SchierTerry L Powley
Apr 4, 2021·Nutrients·Van B LuFrank Reimann

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