PMID: 7517985Feb 1, 1994Paper

Suppression of mitochondrial mRNA levels and mitochondrial function in cells responding to the anticellular action of interferon

Journal of Interferon Research
J LouB Y Rubin

Abstract

A lambda cDNA library prepared from polyadenylated RNA isolated from Daudi cells was differentially screened to isolate cDNAs that recognize mRNA whose levels are reduced following interferon (IFN) treatment. Southern blot and DNA sequence analysis of 20 cDNA clones that were isolated revealed that they represented mitochondrially encoded mRNAs for the following proteins: cytochrome c oxidase subunits II and III, ATPase 6, cytochrome b, and subunit 1 of the NADH dehydrogenase. Northern blot analysis employing these cDNAs and oligonucleotides generated to the remaining mitochondrially encoded mRNAs demonstrated that IFN-alpha treatment of Daudi cells mediates a time-dependent suppression of the level of all of the mitochondrially encoded mRNAs. Study of this IFN-mediated effect reveals that: (i) the suppression of the level of these mRNAs is dependent on protein synthesis, (ii) it can be observed to occur prior to any detectable effect on thymidine incorporation, (iii) the degree of suppression correlates with the sensitivity of the cells to the anticellular action of IFN, and (iv) the suppression of the level of these RNAs appears to result from an effect on the level of transcription rather than on the stability of these mRNAs...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G M WahlG R Stark
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M EinatA Kimchi
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K C ZoonH Arnheiter
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C DaniJ M Blanchard
Jan 1, 1964·Biochemical and Biophysical Research Communications·J Taylor
Aug 1, 1982·European Journal of Biochemistry·R H SilvermanI M Kerr
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R A Young, R W Davis
Nov 1, 1982·The Journal of Cell Biology·D L Granger, A L Lehninger
Aug 1, 1983·The Journal of General Virology·B Y RubinW A Martimucci

❮ Previous
Next ❯

Citations

Jan 1, 1995·Pharmacology & Therapeutics·B Fromenty, D Pessayre
Nov 10, 2000·Biochimica Et Biophysica Acta·K H KainN K Herzog
Mar 26, 2003·Cytokine & Growth Factor Reviews·Timothy A Stewart
Jan 27, 2006·Molecular Biology of the Cell·Olga MoiseevaGerardo Ferbeyre
Jun 19, 2012·Trends in Cell Biology·Karol SzczepanekAndrew C Larner
Apr 3, 2007·Biochimie·Catherine Bisbal, Robert H Silverman
Feb 18, 2006·Developmental Medicine and Child Neurology·Christine BarnériasPascale de Lonlay
May 31, 1996·The Journal of Biological Chemistry·J A LewisP Najarro
May 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·H InagakiY Kitagawa
May 19, 2005·Cancer Research·Stéphanie GrandemangeChantal Wrutniak-Cabello

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Biological Chemistry
J A LewisP Najarro
Biochemical and Biophysical Research Communications
S KawachiM B Grisham
© 2021 Meta ULC. All rights reserved