Suppression of murine cardiac allograft arteriopathy by long-term blockade of CD40-CD154 interactions

Circulation
Catherine Y WangD J Pinsky

Abstract

The interaction between CD40 on antigen-presenting cells and CD40L on T cells is critical in allograft rejection. CD154 blockade suppresses allograft rejection, but the role of this pathway in allograft vasculopathy remains obscure. A vascularized murine heterotopic cardiac transplant model was used to test whether perioperative CD154 blockade suppresses allograft vasculopathy or whether long-term CD154 blockade is required to suppress allograft vasculopathy. Perioperative CD154 blockade consisted of MR1 given on days -1, 1, and 3; long-term blockade consisted of MR1 given on days -1, 1, and 3 and continued twice weekly for 8 weeks. Allografts treated with perioperative or long-term CD154 blockade survived indefinitely. Perioperative and long-term treatment with control antibody (Ha4/8) resulted in uniform early rejection. Perioperative CD154 blockade transiently reduced early T-cell and macrophage infiltration in parallel with a transient reduction in endothelial adhesion receptor expression. Although perioperative CD154 blockade prevented allograft failure, it did not reduce allograft vasculopathy; mean neointimal cross-sectional area in perioperative MR1-treated and Ha4/8-treated recipients was 43+/-7% and 50+/-12%, respecti...Continue Reading

References

Sep 1, 1996·Journal of the American College of Cardiology·S Z GaoE B Stinson
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·W W HancockL A Turka
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·A D KirkS J Knechtle
Jun 13, 2000·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·A FardS Homma
Sep 19, 2000·Virchows Archiv : an International Journal of Pathology·M J SzabolcsM J Yellin

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Citations

Mar 3, 2006·Current Atherosclerosis Reports·Amandeep Dhaliwal, Vinay Thohan
Mar 2, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Masashi TanakaRobert C Robbins
Apr 5, 2007·Nature Protocols·Tomomi HasegawaDavid J Pinsky
May 31, 2008·Cardiovascular Research·Thomas H W StadlbauerMarkus Hecker
Aug 19, 2007·Transplantation·R Neal SmithReza Abdi
Dec 9, 2010·American Journal of Physiology. Endocrinology and Metabolism·Konstantinos DrosatosIra J Goldberg
Jun 3, 2008·Journal of Lipid Research·Tae-Sik ParkIra J Goldberg
Mar 25, 2008·International Heart Journal·Hitoshi SaikiToshimitsu Uede
Jun 16, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Paulo J C LinPieter R Cullis
Apr 26, 2011·Transplant Immunology·Chengwen LiYouping Li
Dec 11, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A D KirkW M Baldwin
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S J HuddlestonM K Jenkins
Jun 12, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R GotoK J Wood
Mar 20, 2008·The American Journal of Pathology·Guohong LiIan J Sarembock
Jul 6, 2012·Expert Opinion on Therapeutic Targets·Jun-ichi SuzukiMitsuaki Isobe
Feb 6, 2003·The Journal of Clinical Investigation·Hiroaki YagyuIra J Goldberg
Sep 23, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Hisanori KosugeToshimitsu Uede
Apr 22, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Mitsuaki IsobeJun-Ichi Suzuki
Sep 18, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Noritaka KogaMitsuaki Isobe
Dec 14, 2002·Circulation Research·Sean P Mazer, David J Pinsky
Jun 5, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Hisanori KosugeToshimitsu Uede
Jul 30, 2003·Circulation·Christopher R LongoChristiane Ferran
Feb 18, 2005·European Heart Journal·Thor UelandJan K Damås
Jan 18, 2006·The Journal of Biological Chemistry·Ayanna S AugustusIra J Goldberg
Jan 27, 2005·The Journal of Pharmacology and Experimental Therapeutics·Reeba K VikramadithyanIra J Goldberg
Mar 5, 2003·Pharmacological Reviews·Jan H von der ThüsenErik A L Biessen
Feb 5, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Linghua KongShi-Fang Yan
Oct 5, 2017·Journal of Nephropathology·Wisit CheungpasitpornStephen B Erickson
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph P SandersonB Kevin Park
Aug 14, 2019·Frontiers in Immunology·Matthias MezgerHarald F Langer

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