Abstract
Exposure of murine lymphocytes to the carcinogenic polycyclic aromatic hydrocarbon 7,12-dimethylbenz[a]anthracene (DMBA) results in significant suppression of a variety of immunological parameters, including the induction of cytotoxic T-lymphocytes (CTL). This CTL suppression may be reversed in vitro by the addition of exogenous cellular activation products, including IL-2. The current study demonstrated that DMBA-induced CTL suppression occurs throughout the induction process, with the most pronounced effect occurring within 24-48 h of initiation. IL-2-mediated restoration of suppression is effective only within this critical window. These findings suggest an effect by DMBA on both the T-helper (Th) and CTL-precursor (CTLp) subsets. Alloantigen-specific CTL generated from murine thymocytes in the presence of DMBA and Th-derived factors (thus circumventing the Th) displayed an almost identical degree of CTL suppression to that of splenocytes, indicating a direct effect of DMBA on the CTLp. Antigen nonspecific, polyclonal CTL activation by the lectin leucoagglutinin or by IL-2 (LAK cells) was unaffected by chemical exposure, indicating that DMBA preferentially affects antigen-specific activation rather than the cytolytic process...Continue Reading
References
Jul 1, 1976·Cellular Immunology·Y ReisnerN Sharon
Oct 1, 1975·The Journal of Experimental Medicine·J NedrudW R Clark
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·O LeoJ A Bluestone
Mar 1, 1987·Human Immunology·H C Oettgen, C Terhorst
Jan 1, 1987·International Journal of Immunopharmacology·R V HouseJ H Dean
Jan 1, 1986·International Journal of Immunopharmacology·E C WardJ H Dean
Jan 1, 1986·International Journal of Immunopharmacology·J H DeanD O Adams
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K TakatsuA Tominaga
Oct 1, 1985·Cellular Immunology·V J Merluzzi
Oct 17, 1985·Nature·I N CrispeU D Staerz
Mar 1, 1984·Cellular Immunology·V J MerluzziK Welte
Nov 1, 1984·Cellular Immunology·E L LarssonA Coutinho
Jan 1, 1983·Immunological Reviews·G Berke
Jan 1, 1983·Immunological Reviews·E MartzS H Gromkowski
Sep 15, 1984·Toxicology and Applied Pharmacology·E C WardJ H Dean
Jan 1, 1987·Immunology Today·P Hersey, R Bolhuis
Citations
Jan 1, 1989·Chemico-biological Interactions·L M ThurmondJ H Dean
Jan 1, 1993·Molecular Aspects of Medicine·R Burrell
Jan 1, 1991·International Journal of Immunopharmacology·S W BurchielD A Davis
Apr 1, 1992·International Journal of Immunopharmacology·M PallardyC Bohuon
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M M ArchuletaS W Burchiel
Jun 1, 1995·Journal of Toxicology and Environmental Health·D R DavilaS W Burchiel
Jul 30, 2005·Clinical & Developmental Immunology·Jennifer C C NealeM Eric Gershwin
Mar 1, 1992·Toxicology and Applied Pharmacology·M M ArchuletaS W Burchiel
Oct 1, 1992·Toxicology and Applied Pharmacology·D A Davis, S W Burchiel
Jun 19, 2004·International Journal of Toxicology·Jack H Dean
Mar 17, 2017·Journal of Neurosurgery·Cole A GillerJean-François Moreau
Nov 24, 1999·Toxicology and Applied Pharmacology·K K MannD H Sherr
Sep 15, 1990·Toxicology and Applied Pharmacology·S W BurchielL C Seamer