PMID: 2495255Jan 1, 1989Paper

Suppression of murine cytotoxic T-lymphocyte induction following exposure to 7,12-dimethylbenz[A]anthracene: dysfunction of antigen recognition

International Journal of Immunopharmacology
R V HouseJ H Dean

Abstract

Exposure of murine lymphocytes to the carcinogenic polycyclic aromatic hydrocarbon 7,12-dimethylbenz[a]anthracene (DMBA) results in significant suppression of a variety of immunological parameters, including the induction of cytotoxic T-lymphocytes (CTL). This CTL suppression may be reversed in vitro by the addition of exogenous cellular activation products, including IL-2. The current study demonstrated that DMBA-induced CTL suppression occurs throughout the induction process, with the most pronounced effect occurring within 24-48 h of initiation. IL-2-mediated restoration of suppression is effective only within this critical window. These findings suggest an effect by DMBA on both the T-helper (Th) and CTL-precursor (CTLp) subsets. Alloantigen-specific CTL generated from murine thymocytes in the presence of DMBA and Th-derived factors (thus circumventing the Th) displayed an almost identical degree of CTL suppression to that of splenocytes, indicating a direct effect of DMBA on the CTLp. Antigen nonspecific, polyclonal CTL activation by the lectin leucoagglutinin or by IL-2 (LAK cells) was unaffected by chemical exposure, indicating that DMBA preferentially affects antigen-specific activation rather than the cytolytic process...Continue Reading

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Citations

Jan 1, 1989·Chemico-biological Interactions·L M ThurmondJ H Dean
Jan 1, 1993·Molecular Aspects of Medicine·R Burrell
Jun 1, 1995·Journal of Toxicology and Environmental Health·D R DavilaS W Burchiel
Oct 1, 1992·Toxicology and Applied Pharmacology·D A Davis, S W Burchiel
Jun 19, 2004·International Journal of Toxicology·Jack H Dean
Mar 17, 2017·Journal of Neurosurgery·Cole A GillerJean-François Moreau

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