Suppression of murine experimental autoimmune encephalomyelitis development by 1,25-dihydroxyvitamin D3 with autophagy modulation

Journal of Neuroimmunology
Chao ZhenLi Guo

Abstract

Multiple sclerosis (MS) has been associated with a history of sub-optimal exposure to ultraviolet light, implicating vitamin D3 as a possible protective agent. We evaluated whether 1,25(OH)2D3 attenuates the progression of experimental autoimmune encephalomyelitis (EAE), and explored its potential mechanisms. EAE was induced in C57BL/6 mice via immunization with MOG35-55, and some mice received 1,25(OH)2D3. 1,25(OH)2D3 inhibited EAE progression. Additionally, 1,25(OH)2D3 reduced inflammation, demyelination, and neuron loss in the spinal cord. The protective effect of 1,25(OH)2D3 was associated with significantly elevated expression of Beclin1, increased Bcl-2/Bax ratio, and decreased LC3-II accumulation. Thus, 1,25(OH)2D3 may represent a promising new MS treatment.

References

Mar 1, 1991·The Journal of Clinical Investigation·J M Lemire, D C Archer
Jan 20, 2005·Molecular and Cellular Biology·Patricia BoyaGuido Kroemer
Jun 30, 2005·Journal of Cell Science·Rosa-Ana González-PoloGuido Kroemer
Apr 28, 2006·Acta Neurologica Scandinavica. Supplementum·L BöP van der Valk
Sep 27, 2006·Molecular Aspects of Medicine·Barry Boland, Ralph A Nixon
Feb 28, 2007·Neurology·Istvan PirkoRohit Bakshi
Apr 21, 2007·The EMBO Journal·M Chiara MaiuriGuido Kroemer
Apr 25, 2007·Neurology·D H MillerUNKNOWN AFFIRM Investigators
Jul 6, 2007·Autophagy·Noboru Mizushima, Tamotsu Yoshimori
Aug 25, 2007·Nature Reviews. Molecular Cell Biology·M Chiara MaiuriGuido Kroemer
Sep 7, 2007·Journal of Neuropathology and Experimental Neurology·Jeroen J G GeurtsPaul van der Valk
Jul 17, 2008·The Journal of Biological Chemistry·Jianrong WangSamantha Spindel
Sep 23, 2008·Developmental Cell·Francesco Cecconi, Beth Levine
Oct 9, 2008·Current Opinion in Neurobiology·Sharon A Tooze, Giampietro Schiavo
Jan 27, 2009·Biochimica Et Biophysica Acta·Ning Chen, Vassiliki Karantza-Wadsworth
Mar 27, 2009·Brain : a Journal of Neurology·Jorge CorrealeMaría Inés Gaitán
Jun 17, 2009·Cell Host & Microbe·Vojo Deretic, Beth Levine
Sep 15, 2009·Cell Host & Microbe·Jae-Min YukEun-Kyeong Jo
Sep 16, 2009·Archives of Neurology·Massimiliano CalabreseMassimo Filippi
Dec 26, 2009·Current Opinion in Cell Biology·Zhifen Yang, Daniel J Klionsky
Apr 12, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Steve SimpsonBruce Taylor
Dec 14, 2011·BMC Neurology·Hanneke E Hulst, Jeroen J G Geurts
Jun 15, 2012·Journal of Magnetic Resonance Imaging : JMRI·René M VigevenoFrederik Barkhof
Apr 4, 2014·Journal of Neuroimmunology·Masaaki NiinoSeiji Kikuchi

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