Suppression of Mycobacterium tuberculosis induced reactive oxygen species (ROS) and TNF-alpha mRNA expression in human monocytes by allicin

FEBS Letters
Nazarul HasanNajmul Islam

Abstract

Chronic inflammation associated with tumor necrosis factor (TNF)-alpha and reactive oxygen species (ROS) is the hallmark of tuberculosis. Mycobacterium tuberculosis (MTB) directly stimulates human monocytes to secrete TNF-alpha. We show the augmented expression of TNF-alpha mRNA in MTB-infected monocytes by cellular activation and ROS was suppressed by allicin in a dose-dependent manner. Also, allicin enhanced the glutathione peroxidase activity, which correlated inversely with the downregulation of ROS and TNF-alpha in MTB-infected monocytes. Hence, allicin may prove to be a valuable natural antioxidant in combating tuberculosis.

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Citations

Apr 23, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Wei HuangHong-Li Sun
Jul 1, 2008·Indian Journal of Clinical Biochemistry : IJCB·Nasreen NoorFarzana Bano
Jan 22, 2010·International Immunology·Veronika BensonAnna Fiserova
Jan 20, 2016·Antioxidants·Tomoko Kurita-OchiaiMasafumi Yamamoto
May 29, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yang LiuHongli Sun
Feb 17, 2007·Biochemical and Biophysical Research Communications·Nazarul HasanNajmul Islam
May 17, 2013·Pharmaceutical Biology·Nora A AshryGhada M Suddek
Jul 15, 2016·Chinese Journal of Integrative Medicine·Li-Na MaYi-Kui Li
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roberta GalliAnna Riccioli
Feb 15, 2017·Frontiers in Microbiology·Amar M YewareDhiman Sarkar
Jun 5, 2020·Heart Failure Reviews·Parinaz ZivarpourZatollah Asemi
Feb 24, 2021·Antimicrobial Agents and Chemotherapy·Catherine Vilchèze, William R Jacobs
Jun 14, 2021·Environmental Science and Pollution Research International·Hanan A EdresMohamed S Elfeky

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