PMID: 7333710Dec 1, 1981Paper

Suppression of natural killer (NK) activity by splenic adherent cells of low NK-reactive mice

International Journal of Cancer. Journal International Du Cancer
C RiccardiR B Herberman

Abstract

Adherent cells with the ability to inhibit NK activity were found in the spleens of young 8-week-old SJL/J mice. Such suppressor cells were also found in the spleens of other low-NK-reactive strains, but not in the spleen of age-matched high-NK-reactive strains. These suppressor cells had the characteristics of macrophages, since they were plastic- and nylon-adherent, phagocytosed latex and iron particles, and were resistant to treatment with anti-Thy-1.2 serum plus complement. Their inhibitory activity appeared to be due to their production and/or release of soluble suppressive factor(s). Their suppressor activity was similar to that of pyran copolymer-activated macrophages, which were previously shown to be suppressive for cytotoxicity by NK cells. We suggest here that macrophages may be involved in the physiological regulation of NK activity and may contribute to the low NK activity in some strains of mice.

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Citations

Oct 26, 1988·Journal of Immunological Methods·S Lemieux, F Ouellet-Talbot
Sep 14, 1987·Mechanisms of Ageing and Development·P B BlairJ S Sam
Oct 1, 1982·Molecular Immunology·R B Herberman
Jan 1, 1984·International Journal of Immunopharmacology·G MiglioratiC Riccardi
Jan 1, 1987·Experimental Lung Research·K NuntiroojJ E Salvaggio
May 15, 1982·International Journal of Cancer. Journal International Du Cancer·E GorelikR B Herberman
Mar 15, 1983·International Journal of Cancer. Journal International Du Cancer·S A StohlmanG K Matsushima
Mar 15, 1983·International Journal of Cancer. Journal International Du Cancer·C RiccardiR B Herberman
Jan 15, 1983·International Journal of Cancer. Journal International Du Cancer·G MiglioratiC Riccardi
Jul 1, 1985·Mechanisms of Ageing and Development·N IrimajiriT Makinodan
Jul 15, 1986·International Journal of Cancer. Journal International Du Cancer·G MiglioratiC Riccardi
Jan 1, 1990·Immunopharmacology and Immunotoxicology·A SantoniL Frati

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