Suppression of NLRP3 inflammasome attenuates stress-induced depression-like behavior in NLGN3-deficient mice

Biochemical and Biophysical Research Communications
Ze-Qun LiYe Xiong

Abstract

Depression, regulated by central nervous system (CNS), is a significant inflammatory disorder. Neuroligin3 (NLGN3) has been implicated in brain functions. In the study, a chronic unpredictable mild stress (CUMS) model in wild type (WT) or NLGN3-knockout (KO) mice was established to explore the role of NLGN3 in regulating depression and to reveal the underlying molecular mechanism. The results indicated that NLGN3-knockout markedly reversed the loss of body weight, the reduction of sucrose consumption, the decrease of immobile time in the forced swimming tests (FST) and tail suspension tests (TST) induced by CUMS paradigm. CUMS up-regulated corticosterone (CORT) in serum, and down-regulated serotonin (5-HT), norepinephrine (NE) and brain-derived neurotrophic factor (BDNF) in hippocampus of mice, which were significantly reversed by NLGN3 deficiency. The results further demonstrated that NLGN3-knockout improved the degenerative neurons in cortex and hippocampus of CUMS-treated mice, accompanied with a significant decrease of ionized calciumbinding adapter molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) expressions. Additionally, NLGN3-KO mice challenged with CUMS showed a significant reduction of pro-inflammatory cy...Continue Reading

Citations

Oct 1, 2019·Annual Review of Psychology·Joana S Cruz-PereiraJohn F Cryan
Jan 1, 2021·International Journal of Molecular Sciences·Thomas Ho-Yin Lee, Suk-Yu Yau
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Girdhari Lal Gupta, Joneth Fernandes
Dec 5, 2020·Neurochemistry International·Guangcong PengGuang Q Zhang

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