Suppression of ovalbumin-induced airway inflammatory responses in a mouse model of asthma by Mimosa pudica extract

Phytotherapy Research : PTR
Eun Ju YangIn Sik Kim

Abstract

Asthma is an inflammatory airway disease. The pathogenic mechanisms of asthma include the infiltration of leukocytes and release of cytokines. Mimosa pudica (Mp) has been used traditionally for the treatment of insomnia, diarrhea and inflammatory diseases. Although Mp extract has various therapeutic properties, the effect of this extract on asthma has not yet been reported. This study investigated the suppressive effects of Mp extract on asthmatic responses both in vitro and in vivo. Mp extract was acquired from dried and powdered whole plants of M. pudica using 80% ethanol. BALB/c mice were used for the mouse model of asthma induced by ovalbumin. Mp extract significantly inhibited the HMC-1 cell migration induced by stem cell factor and blocked the release of monocyte chemotactic protein-1 (MCP-1) and interleukin-6 (IL-6) in EoL-1 cells. Leukocytosis, eosinophilia and mucus hypersecretion in asthmatic lung were significantly suppressed by Mp extract. The release of ovalbumin-specific IgE in bronchoalveolar lavage fluid and serum was also decreased. Mp extract treatment resulted in no liver cytotoxicity. The Mp extract has inhibitory properties on asthma and may be used as a potent therapeutic agent for allergic lung inflammation.

References

Aug 1, 1990·The American Review of Respiratory Disease·R DjukanovićS T Holgate
Mar 20, 1998·International Reviews of Immunology·T Hirano
May 4, 1999·International Archives of Allergy and Immunology·D S RobinsonA B Kay
Mar 17, 2000·The Journal of Allergy and Clinical Immunology·S Romagnani
Mar 10, 2001·The Journal of Allergy and Clinical Immunology·L G Arlian, T A Platts-Mills
Sep 18, 2002·Fitoterapia·T Amalraj, S Ignacimuthu
Mar 6, 2003·The Journal of Allergy and Clinical Immunology·William W Busse, Lanny J Rosenwasser
Jun 12, 2003·International Journal of Immunopathology and Pharmacology·S FrydasI Vlemmas
May 22, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Bita ShakooryGuha Krishnaswamy
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei DuanW S Fred Wong
May 26, 2004·Fitoterapia·E Ngo BumP Herrling
Dec 14, 2004·Current Opinion in Pulmonary Medicine·Leslie R Bisset, Peter Schmid-Grendelmeier
Aug 10, 2005·Seminars in Respiratory and Critical Care Medicine·Prescott G Woodruff, John V Fahy
Dec 2, 2005·The European Respiratory Journal·S N GeorasV Casolaro
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Peter BraddingStephen T Holgate
Jul 15, 2006·Chest·Sidney S Braman
May 2, 2007·British Journal of Pharmacology·C PalmqvistP Bradding
Feb 16, 2008·Nature Reviews. Immunology·Stephen T Holgate, Riccardo Polosa
May 24, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Stephen T Holgate
Mar 3, 2009·Biological & Pharmaceutical Bulletin·Emiko IwaokaKyoko Ishiguro
Apr 29, 2009·Journal of Ethnopharmacology·Dnyaneshwar D KokaneChhaya H Gadgoli

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Citations

Feb 28, 2015·Journal of Ethnopharmacology·Niharika SinghDinkar Sahal
Mar 22, 2015·Journal of Ethnopharmacology·Prakash Roy ChoudhuryAnupam Das Talukdar
Apr 11, 2017·Molecular Medicine Reports·Bin XuYingming Zhang
Jul 1, 2017·International Journal of Inflammation·N A KamalaldinB Yahaya
May 4, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Gopalsamy Rajiv GandhiRicardo Queiroz Gurgel

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