Suppression of oxidative stress and pro-inflammatory mediators by Cymbopogon citratus D. Stapf extract in lipopolysaccharide stimulated murine alveolar macrophages

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M TiwariP Kakkar

Abstract

Exploration of antioxidants of plant origin and their scientific validation for their immense pharmacological potential is emerging as an issue of intense research now-a-days.The effect of Cymbopogon citratus extract was seen on cell viability, oxidative stress markers i.e. ROS production, SOD activity, lipid peroxidation and GSH content of murine alveolar macrophages stressed with lipopolysaccharide. Modulation in release of NO and pro-inflammatory cytokine TNF-α along with alterations in mitochondrial membrane potential under stress were compared with known plant derived antioxidant quercetin. The extract was not found to be cytotoxic at any of the selected doses. At 5 and 10 μg the extract showed significant increase in SOD activity, GSH content (p<0.001), decrease in ROS production as seen by fluorescent dye DCFH-DA and also MDA formation (lipid peroxidation marker) significantly. The extract also showed reduction in the release of pro-inflammatory mediators TNF-α and NO significantly indicating an anti-inflammatory effect. The extract was able to restore mitochondrial membrane potential as estimated by spectrofluorimetry using the fluorescent dye Rhodamine 123. The results suggest potential use of the cytoprotective, antio...Continue Reading

References

Jan 1, 1995·Advances in Neuroimmunology·F Y Liew
Jan 1, 1996·Free Radical Biology & Medicine·Y RongB H Lau
Sep 16, 2000·Biochemical Society Symposium·G C Brown, V Borutaite
Jan 10, 2002·Pulmonary Pharmacology & Therapeutics·P A Henricks, F P Nijkamp
Jun 12, 2004·Apoptosis : an International Journal on Programmed Cell Death·T Kuwabara, S Imajoh-Ohmi
Oct 7, 2004·Critical Reviews in Food Science and Nutrition·Joye K WillcoxGeorge L Catignani
Oct 22, 2004·Molecular Nutrition & Food Research·Chia-Pei LiangChi-Tang Ho
Mar 3, 2005·Journal of Pharmaceutical and Biomedical Analysis·Cristiane da S RauberElfrides E S Schapoval
Feb 7, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S VandanaP K Banerjee
Feb 25, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association· KanupriyaP K Banerjee
Feb 28, 2006·European Journal of Pharmacology·Irfan RahmanAruna Kode
Nov 1, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Po-Jung TsaiSu-Chen Ho
Nov 24, 2006·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·S SunL Luo
Jan 30, 2007·Prostaglandins & Other Lipid Mediators·D P Mishra, A Dhali
May 22, 2007·Journal of Ethnopharmacology·Adejuwon Adewale Adeneye, Esther Oluwatoyin Agbaje
Jun 26, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Valéry AfonsoAbderrahim Lomri
Aug 9, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Renato Moreira RosaJenifer Saffi
Dec 18, 2007·Journal of Agricultural and Food Chemistry·Toshiya MasudaHideki Kuninaga
Sep 24, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Madhulika TripathiPoonam Kakkar

❮ Previous
Next ❯

Citations

Mar 5, 2014·European Journal of Medicinal Chemistry·Maria E S B BarrosPaulo H Menezes
Dec 19, 2013·PloS One·Larissa Cardoso Corrêa AraújoPatrícia Maria Guedes Paiva
Nov 7, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yuan GaoYun Qi
Feb 3, 2016·Frontiers in Pharmacology·Sara S Al DisiAli H Eid
May 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saritha SurapaneniDivakar Goli
Nov 13, 2014·Journal of the Science of Food and Agriculture·Filipa TavaresMaria Teresa Batista
Jul 19, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Nancy Sayuri UchidaRoberto Kenji Nakamura Cuman
Aug 12, 2014·Molecular Biology Reports·Marilia de Paula PortoDaisy Maria Fávero Salvadori
Mar 21, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Hellen Braga MartinsLucas M Marques
Mar 28, 2019·BioMed Research International·Xincai HaoYonghui Zhang
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raquel SousaMaria Eugénia Pina

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.