PMID: 2509621Oct 1, 1989Paper

Suppression of pituitary-testis function in rats treated neonatally with a gonadotrophin-releasing hormone agonist and antagonist: acute and long-term effects

The Journal of Endocrinology
K L Kolho, I Huhtaniemi

Abstract

The acute and long-term effects of pituitary-testis suppression with a gonadotrophin-releasing hormone (GnRH) agonist, D-Ser(Bu(t))6des-Gly10-GnRH N-ethylamide (buserelin; 0.02, 0.1, 1.0 or 10 mg/kg body weight per day s.c.) or antagonist, N-Ac-D-Nal(2)1,D-p-Cl-Phe2,D-Trp3,D-hArg(Et2)6,D-Ala10 -GnRH (RS 68439; 2 mg/kg body weight per day s.c.) were studied in male rats treated on days 1-15 of life. The animals were killed on day 16 (acute effects) or as adults (130-160 days; long-term effects). Acutely, the lowest dose of the agonist decreased pituitary FSH content and testicular LH receptors, but with increasing doses pituitary and serum LH concentrations, intratesticular testosterone content and weights of testes were also suppressed (P less than 0.05-0.01). No decrease was found in serum FSH or in weights of accessory sex organs even with the highest dose of the agonist, the latter finding indicating continuing secretion of androgens. The GnRH antagonist treatment suppressed pituitary LH and FSH contents and serum LH (P less than 0.05-0.01) but, as with the agonist, serum FSH remained unaltered. Testicular testosterone and testis weights were decreased (P less than 0.01) but testicular LH receptors remained unchanged. Moreov...Continue Reading

Citations

Jan 1, 1991·Annals of the New York Academy of Sciences·I T HuhtaniemiD W Warren
Apr 15, 2014·Theriogenology·A CarranzaC Gobello
Jun 27, 2013·Theriogenology·M FayaC Gobello
Jul 22, 2018·General and Comparative Endocrinology·Morgan A MalyAdrienne E Crosier
Dec 1, 2021·Reproduction, Fertility, and Development·Morgan A MalyAdrienne E Crosier

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