Suppression of PPN/MG61 attenuates Wnt/beta-catenin signaling pathway and induces apoptosis in human lung cancer

Oncogene
Z ChenH M Zhou

Abstract

Wingless and int homologue (Wnt) family proteins have been shown to have important roles in the decision of cell fate and behavior at multiple stages during the development and tumorigenesis. One of the Drosophila segment polarity genes, porcupine (porc) gene, encodes an evolutionarily conserved endoplasmic reticulum membrane protein involving in the post-translational processing of the Wnt family proteins. Here, we report that human homologue of Drosophila porc gene, PPN/MG61, was abundantly expressed in human cancer cell lines, but not in normal cells. We also found that PPN/MG61 was overexpressed in primary lung cancer tissue samples, compared to their matched normal tissue samples. Furthermore, when we used small interfering RNA to knock down PPN/MG61 mRNA in lung cancer cells expressing the gene, we observed apoptosis induction, along with decreased activity of Wnt pathway in those lung cancer cells. These data suggest that PPN/MG61 may be a novel marker for human lung cancer and that post-translational modification of the Wnt signal molecules by PPN/MG61 may be important for the function of Wnt pathway in lung cancer.

References

Jun 24, 2000·European Journal of Biochemistry·K TanakaT Kadowaki
Aug 26, 2000·Cytokine & Growth Factor Reviews·T Akiyama
Jun 28, 2002·Cancer Cell·Ashani T WeeraratnaJeffrey M Trent
Sep 12, 2003·Developmental Cell·Michael T VeemanRandall T Moon
Apr 8, 2004·Neoplasia : an International Journal for Oncology Research·Biao HeDavid M Jablons
Sep 17, 2004·Nature Reviews. Genetics·Randall T MoonAjamete Kaykas
Apr 15, 2005·Nature·Tannishtha Reya, Hans Clevers
May 19, 2005·International Journal of Cancer. Journal International Du Cancer·Julien MazieresDavid M Jablons
May 26, 2005·BMC Cancer·Iwao MikamiDavid M Jablons
Dec 5, 2006·Oncogene·A J Mikels, R Nusse

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Citations

Feb 10, 1986·Life Sciences·E O McFallsA L Shug
Mar 13, 2013·Journal of Medicinal Chemistry·Xiaolei WangChuo Chen
Mar 5, 2009·The Journal of Chemical Physics·Qiang ShiYijing Yan
Dec 7, 2013·Journal of the National Cancer Institute·David J Stewart
Oct 5, 2010·Annual Review of Pharmacology and Toxicology·Michael E Dodge, Lawrence Lum
Jan 27, 2009·Molecular Membrane Biology·Shu-Chun Chang, Anthony I Magee
Jun 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guo XiangWu Weiming
Dec 17, 2015·Future Medicinal Chemistry·Shilong ZhengGuangdi Wang
Aug 14, 2010·Fetal and Pediatric Pathology·Cristina DiasMargarida Lima
Jul 15, 2015·BMC Cancer·Richard NeapolitanXia Jiang
Jun 17, 2016·Clinical Proteomics·Gajanan SatheAditi Chatterjee
Oct 4, 2011·Biomedical Microdevices·Doug T ValassisJoseph L Bull
Nov 6, 2018·Biomedicines·Eike-Benjamin BrauneUrban Lendahl
Aug 14, 2012·The Journal of Biological Chemistry·Kyle D Proffitt, David M Virshup
Jan 26, 2021·International Journal of Pharmaceutics·Noa Ben Ghedalia-PeledRazi Vago

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