Suppression of secretagogue-induced amylase secretion in pancreatic acini of cold-exposed rats.

The Journal of Physiology
Y Habara

Abstract

1. The influence of prolonged exposure to a low ambient temperature on the pancreatic exocrine function was investigated in rats. Amylase concentration in acini prepared from rats housed at 5 degrees C for 2 weeks was specifically and dramatically reduced. The enzyme activity relative to acinar DNA concentration was only 48% of that of control acini obtained from rats reared at the thermoneutral temperature of 25 degrees C. Amylase content relative to acinar protein concentration also decreased by 35%. In contrast, acinar trypsinogen content relative to protein concentration increased to 161% of that of control acini. No comparable change was found in the parotid glands. 2. In acini from cold-exposed rats, amylase release in response to cholecystokinin octapeptide or carbamylcholine was simultaneously reduced when expressed relative to acinar DNA or protein concentration and the dose-response curve shifted downward. However, when the secretory responsiveness of amylase was represented as a percentage of initial acinar enzyme content, the observed decrease disappeared and the dose-response curve was unaffected by cold exposure. 3. Secretagogue-stimulated trypsinogen release was augmented in acini from cold-exposed rats when expr...Continue Reading

Citations

Sep 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·K R PurushothamT Zelles
Sep 26, 2014·American Journal of Physiology. Cell Physiology·Amira Moustafa, Yoshiaki Habara
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·E Harada
Nov 1, 1991·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·Y HabaraT Kanno

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