Suppression of SMOC2 reduces bleomycin (BLM)-induced pulmonary fibrosis by inhibition of TGF-β1/SMADs pathway

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Li LuoFu-Yang Pei

Abstract

Although the initiation and modulation of lung fibrosis has been widely investigated, the pathogenesis was not well understood. Secreted modular calcium-binding protein 2 (SMOC2) as the secreted protein acidic is enriched in cysteine (SPARC) family of matricellular proteins, which are important in regulating cell-matrix interactions. Here we aimed to calculate the effects and molecular mechanism of SMOC2 on the progression and severity of lung fibrosis in murine bleomycin (BLM)-induced mice. The pulmonary fibrosis was significantly induced by BLM in wild type (WT) C57BL6 mice, as evidenced by the lung sections histology and collagen accumulation using H&E and Masson Trichrome staining. Notably, SMOC2 knockout (SMOC2-/-) mice treated with BLM exhibited the decrease in inflammation accompanied by the reduction of neutrophils, macrophages and lymphocytes in bronchoalveolar lavage fluids (BALF). In addition, the levels of inflammation-associated cytokines and chemokines induced by BLM were also decreased in BALF obtained from SMOC2-/- mice. Meanwhile, SMOC2-/- suppressed the progression of pulmonary fibrosis, as evidenced by the reduction in levels of transforming growth factor-β1 (TGF-β1), α-smooth muscle actin (α-SMA), p-SMAD2 an...Continue Reading

References

Mar 10, 2001·The American Journal of Pathology·G KrishnaG D Rosen
Aug 25, 2001·The New England Journal of Medicine·T J Gross, G W Hunninghake
Jun 16, 2006·The Journal of Biological Chemistry·Edward F RocnikCyrus Vaziri
Nov 13, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bethany B Moore, Cory M Hogaboam
Dec 19, 2007·The Journal of Cell Biology·Pierre-Jean WipffBoris Hinz
Jul 22, 2008·Head & Neck·Yu ChenLester Jack Windsor
Nov 17, 2009·Journal of Cell Communication and Signaling·Shangxi LiuAndrew Leask
Jul 20, 2011·The International Journal of Developmental Biology·Ellen Van Obberghen-SchillingGertraud Orend
Oct 29, 2011·The American Journal of Pathology·Craig S Moore, Stephen J Crocker
Mar 8, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jun XiaoHui Y Lan
Mar 24, 2012·The European Respiratory Journal·Akihiro TakemasaTakeshi Fukuda
Sep 21, 2013·Annual Review of Pathology·Paul J WoltersKirk D Jones
May 20, 2014·The New England Journal of Medicine·Fernando J MartinezGanesh Raghu
Oct 14, 2014·Frontiers in Immunology·Ross Vlahos, Steven Bozinovski
Dec 3, 2014·Journal of Autoimmunity·Antoine FrançoisIsabelle Couillin
Jan 18, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Megan N BallingerTheodore J Standiford
Apr 22, 2015·Annals of the American Thoracic Society·Daniel J WeissUNKNOWN ATS Subcommittee on Stem Cells and Cell Therapies
May 12, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Boris Hinz
May 27, 2015·Clinical and Experimental Pharmacology & Physiology·Narayanan SriramGanapasam Sudhandiran
Jun 27, 2015·Clinical and Experimental Pharmacology & Physiology·Fang ZhangYunxia An
Jul 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Sunil K MaloniaMichael R Green
Jul 18, 2015·Science·Matthias Nahrendorf, Filip K Swirski
Oct 24, 2015·Stem Cells Translational Medicine·Nadim Srour, Bernard Thébaud
Mar 5, 2016·American Journal of Respiratory Cell and Molecular Biology·Heather W Stout-DelgadoIvan O Rosas
Apr 12, 2016·Journal of Cellular and Molecular Medicine·Huilin YangJun Zou
Jun 3, 2016·British Journal of Pharmacology·C S SamuelR G Bennett
Jul 5, 2016·The Journal of Allergy and Clinical Immunology·Peter J Barnes

❮ Previous
Next ❯

Citations

Sep 11, 2020·Scientific Reports·Supawich MorkmuedKaren Niederreither
Oct 3, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xiaohe LiWen Ning
Dec 3, 2020·Frontiers in Immunology·Claire E McQuittyLuca Urbani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved