Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis.

Infection and Immunity
Silvia Rossi PaccaniCosima T Baldari

Abstract

The adenylate cyclase toxin (CyaA) released by Bordetella pertussis is an essential virulence factor for colonization of the host. This toxin inhibits migration and activation of phagocytes, thereby preventing bacterial killing. In addition, CyaA interferes with the initiation of adaptive immunity by misdirecting dendritic cell differentiation to a suppressive rather than stimulatory phenotype. Here we show that CyaA directly affects adaptive responses by catalyzing cyclic AMP (cAMP) production in peripheral blood lymphocytes. Treatment with CyaA resulted in profound impairment of T-lymphocyte activation and chemotaxis. These effects resulted from inhibition of T-cell antigen receptor and chemokine receptor signaling via a cAMP/protein kinase A (PKA)-dependent pathway. A comparison of the activities of CyaA on T-cell and macrophage activation and migration revealed that the biological effects of the toxin were paralleled by inhibition of the activation of mitogen-activated protein (MAP) kinases, highlighting the conclusion that the ubiquitous and evolutionarily conserved MAP kinase modules are common targets of the PKA-mediated immunosuppressant activities of CyaA and underlining the potential of cAMP-elevating toxins as a mean...Continue Reading

References

Jan 30, 1987·Biochemical and Biophysical Research Communications·H KaseM Kaneko
Apr 28, 1999·Trends in Microbiology·D Ladant, A Ullmann
Apr 27, 2000·Current Opinion in Immunology·L P KaneA Weiss
Feb 15, 2001·Current Opinion in Microbiology·C LochtF Jacob-Dubuisson
Mar 21, 2001·Cellular Signalling·M Guha, N Mackman
Jul 11, 2001·Microbes and Infection·K H Mills
Dec 19, 2001·Cellular Signalling·Knut Martin TorgersenKjetil Taskén
Feb 28, 2002·Annual Review of Immunology·Chen DongRichard A Flavell
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·S-L Catherine Jin, Marco Conti
Dec 24, 2002·Seminars in Immunology·Mark M Wong, Eleanor N Fish
Sep 25, 2003·Nature Reviews. Molecular Cell Biology·Johannes L Bos
Dec 12, 2003·Nature Reviews. Immunology·Ulrich H von Andrian, Thorsten R Mempel
Dec 17, 2003·The Journal of Experimental Medicine·Marianna BoncristianoCosima T Baldari
Jul 13, 2004·Biochimica Et Biophysica Acta·Alan K Howe
Feb 9, 2005·The Journal of Experimental Medicine·Silvia Rossi PaccaniCosima T Baldari
Jun 10, 2005·FEBS Letters·George S BaillieMiles D Houslay
Jul 1, 2005·Methods in Molecular Biology·Marco MongilloManuela Zaccolo
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aoife P BoydKingston H G Mills
Jan 13, 2006·Current Opinion in Microbiology·Jana VojtovaPeter Sebo
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tone BrynKjetil Taskén
Jul 25, 2006·Trends in Immunology·Cosima T BaldariCesare Montecucco
Nov 4, 2006·The EMBO Journal·Federica Dal MolinCesare Montecucco
Nov 8, 2006·Cellular Microbiology·Silvia Rossi PaccaniCosima T Baldari
Nov 23, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·David M AronoffMarc Peters-Golden
Mar 10, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Magdalena J LorenowiczPeter L Hordijk
Apr 10, 2007·Current Opinion in Pharmacology·Nicholas H Carbonetti
May 11, 2007·The Journal of Biological Chemistry·Jia HongMarsha Rich Rosner
Jun 1, 2007·Blood·Laura PatrussiCosima T Baldari
Apr 27, 2012·Physiological Reviews·John M Kyriakis, Joseph Avruch

❮ Previous
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Citations

Aug 21, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Giorgio FedeleClara Maria Ausiello
May 18, 2011·The Journal of Experimental Medicine·Silvia Rossi PaccaniCosima T Baldari
Mar 13, 2014·Nature Reviews. Microbiology·Jeffrey A MelvinPeggy A Cotter
Feb 13, 2016·Frontiers in Microbiology·Ana do ValeSandra Sousa
Aug 10, 2010·Protein Expression and Purification·Pichaya PojanapothaChanan Angsuthanasombat
Sep 9, 2015·Scientific Reports·César MartínHelena Ostolaza
Mar 5, 2010·Molecular Microbiology·Adriana OsickovaPeter Sebo
Feb 3, 2009·Current Opinion in Microbiology·Ruchi Shrivastava, Jeff F Miller
Dec 8, 2017·PLoS Pathogens·Zachary Freyberg, Eric T Harvill
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xisheng WangBuka Samten
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Olivia D SchneiderWilliam E Miller
Dec 17, 2014·The Journal of Biological Chemistry·Xianzhe WangJennifer A Maynard
Jun 28, 2019·Frontiers in Immunology·Selena ViganoGeorge Coukos
Apr 1, 2016·Clinical Microbiology Reviews·Paul E KilgoreHeinz-Josef Schmitt
Mar 31, 2019·Microbiology Spectrum·Zachary M Nash, Peggy A Cotter
Dec 11, 2021·Science Advances·Zhuoya WanSong Li

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