Suppression of T lymphocyte proliferation by peritoneal macrophages in chickens

Developmental and Comparative Immunology
K DateS Tsuji

Abstract

The mechanism of the suppression of lymphocyte proliferation by peritoneal macrophages (MPs) in chickens and the presence of a suppressive substance in the culture supernatant of MPs were studied. The results showed that gelatin- and peptone-induced peritoneal MPs had an inhibitory accessory function against blastogenesis of mitogen-stimulated splenic lymphocytes and that resident peritoneal MPs had an enhanced accessory function. The suppressive factor produced by gelatin-induced peritoneal MPs is a protein having a pI of 3.6 and a molecular weight of 64,000 and it is physically and chemically a relatively stable substance. Moreover, it has no cytotoxic effect against lymphocytes and it was verified that the suppressor in the culture supernatant of MPs was not prostaglandin E2 or alpha-acid glycoprotein.

References

Jan 1, 1988·Developmental and Comparative Immunology·S H JeurissenG F de Boer
Oct 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·K A TrembickiR R Dietert
Nov 1, 1984·The Journal of Experimental Medicine·R van Furth, M M Diesselhoff-den Dulk

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