Suppression of TGF-β1/Smad signaling pathway by sesamin contributes to the attenuation of myocardial fibrosis in spontaneously hypertensive rats

PloS One
Mengqiu ZhaoJiali Xuan

Abstract

This study investigated the effect of sesamin on myocardial fibrosis in spontaneously hypertensive rats (SHRs) and the possible mechanisms involved. Twenty-eight male SHRs were randomly allocated to SHR group, Ses160 group (sesamin 160 mg/kg), Ses80 group (sesamin 80 mg/kg) and Cap30 group (captopril 30 mg/kg). Seven male WKY rats were used as control. Sesamin and captopril were administered intragastrically for 12 weeks. Captopril significantly reduced systolic blood pressure and angiotensin II (Ang II) levels in SHRs, accompanied by a marked attenuation of left ventricular hypertrophy (LVH) and collagen deposition (P <0.05 or P <0.01). Though sesamin had no significant influence on Ang II levels, and the hypotensive effect was also significantly inferior to that of captopril (P <0.05 or P <0.01), however, the improvement of LVH and collagen deposition was similar to that in captopril group. Sesamin markedly reduced transforming growth factor-β1 (TGF-β1) content in cardiac tissues, with Smad3 phosphorylation decreased and Smad7 protein expression increased notably (P <0.05 or P <0.01). Protein expression of type I collagen and type III collagen, target genes of Smad3, was down-regulated markedly by sesamin (P <0.05 or P <0.01)...Continue Reading

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Citations

Jan 18, 2019·Experimental and Therapeutic Medicine·Yinghong LuHaiyun Jing
Jun 2, 2017·Experimental and Therapeutic Medicine·Rongrong SunPeiying Zhang
Nov 11, 2019·Heart Failure Reviews·Mieczysław DutkaMichał Ćwiertnia
Apr 4, 2017·Experimental Animals·Xian ZhengFengrong Wang
Feb 28, 2018·International Journal of Molecular Medicine·Dongdong WangQunli Wei
Jan 26, 2020·Cells·Chandrakala Aluganti Narasimhulu, Dinender K Singla
Dec 14, 2018·Journal of Translational Medicine·Gianluca Lorenzo PerrucciGiulio Pompilio
Oct 2, 2019·Experimental and Therapeutic Medicine·Xiangyang WuBingren Gao
Feb 28, 2018·International Journal of Molecular Medicine·Xin-Long WangWei Zhu
Nov 6, 2020·Heart Failure Reviews·Mieczysław DutkaMichał Ćwiertnia
Aug 3, 2021·International Heart Journal·Mingjian LangFuping Zhang

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
protein assay
electrophoresis
X-ray
dissection
MDA

Software Mentioned

Image
Pro Plus
SPSS
Quantity One

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