Suppression of Th2 cell development by Notch ligands Delta1 and Delta4.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jie SunEdward J Pearce

Abstract

Notch signaling plays important roles in Th cell activation. We show that in response to TLR ligation, dendritic cells up-regulate expression of Notch ligands Delta1 and Delta4 via a MyD88-dependent pathway. Expression of Delta1 or Delta4 by dendritic cells enhanced their ability to activate naive Th cells and promote Th1 cell development, and allowed them to strongly inhibit Th2 cell development. Promotion of Th1 cell development was dependent on IFN-gamma and T-bet expression by responding Th cells. However, the inhibition of Th2 cell development occurred independently of IFN-gamma or T-bet, and resulted from a block in IL-4-initiated commitment to the Th2 lineage. The promotion of Th1 cell development by Delta is not a reflection of the delivery of pro-Th1 instructional signal, but rather it is the result of a block in the downstream effects initiated by IL-4 signaling.

References

Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·G GeginatH Hof
Feb 14, 2002·Immunology Letters·Etsuko YamaguchiHisamaru Hirai
May 15, 2002·Nature Immunology·Maryam AfkarianKenneth M Murphy
Aug 30, 2002·Current Opinion in Genetics & Development·Alfonso Martinez AriasKeith Brennan
Dec 4, 2002·Nature Reviews. Immunology·Kenneth M Murphy, Steven L Reiner
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott H AdlerWarren S Pear
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tanapat PalagaBarbara A Osborne
Dec 4, 2003·Nature Reviews. Immunology·Martien L Kapsenberg
Apr 16, 2004·Immunity·Todd N EagarJeffrey A Bluestone
Jun 24, 2004·The Journal of Experimental Medicine·Petr BocekWilliam E Paul
Jul 9, 2004·Nature·Sophie M Lehar, Michael J Bevan
Sep 30, 2004·Nature Immunology·Akiko Iwasaki, Ruslan Medzhitov
Oct 12, 2004·Nature Immunology·Jinfang ZhuWilliam E Paul
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shin-Ichi Tsukumo, Koji Yasutomo
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jie SunEdward J Pearce
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zan HuangHua Huang
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masashi WatanabeRyo Abe
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alix de La CosteAntonio A Freitas
Mar 18, 2005·Annual Review of Immunology·Ivan MaillardWarren S Pear
May 24, 2005·Nature Immunology·Kim A BrogdenMichael Zasloff
Sep 6, 2005·Immunology Letters·Alix de La Coste, Antonio A Freitas
Oct 19, 2005·The Journal of Experimental Medicine·Lili TuWarren S Pear
Apr 18, 2006·Current Opinion in Immunology·Laurie E HarringtonCasey T Weaver
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jie Sun, Edward J Pearce
Jun 20, 2007·The Journal of Experimental Medicine·Dimitris Skokos, Michel C Nussenzweig

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Citations

Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sumanta MukherjeeNicholas W Lukacs
Oct 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sihyug JangNicholas W Lukacs
Nov 8, 2011·Immunotherapy·Kazuhiro MochizukiYi Zhang
Aug 5, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ribal BassilSamia J Khoury
Jul 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eyal AmielEdward J Pearce
Dec 25, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sumanta MukherjeeNicholas W Lukacs
Oct 27, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Chen-Chen LeeYueh-Lun Lee
Jan 13, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hung-An TingNicholas W Lukacs
Nov 7, 2019·Open Biology·Joshua D Brandstadter, Ivan Maillard
Jan 24, 2009·Nature Reviews. Immunology·Derk AmsenRichard A Flavell
Apr 21, 2010·European Journal of Immunology·Bart EvertsMaria Yazdanbakhsh
Mar 3, 2010·Annual Review of Immunology·Julie S YuanCynthia J Guidos
Feb 24, 2009·American Journal of Respiratory and Critical Care Medicine·Jin Hyun KangIl Yup Chung
Sep 12, 2009·Expert Opinion on Biological Therapy·Ashley R Sandy, Ivan Maillard
Mar 17, 2012·European Journal of Orthodontics·Li Duan, Yijin Ren
Feb 27, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazuhiro MochizukiYi Zhang
Jun 23, 2018·Frontiers in Immunology·Thibaut PerchetRachel Golub
Jul 20, 2019·International Journal of Molecular Sciences·Miao-Tzu HuangBor-Luen Chiang
Jun 20, 2020·Journal of Leukocyte Biology·Ashley Vanderbeck, Ivan Maillard
Mar 3, 2010·Annual Review of Immunology·Jinfang ZhuWilliam E Paul
Jan 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jun-Qi YangJorge Moscat
Mar 31, 2012·Journal of Leukocyte Biology·Toshihiro ItoAkihiro Matsukawa
Sep 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leonardo V RiellaNader Najafian
Oct 11, 2008·Nature Reviews. Immunology·Jamey D Marth, Prabhjit K Grewal
Mar 31, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Shi LiJinnong Zhang
Sep 9, 2016·Transplantation·Vedran Radojcic, Ivan Maillard
May 2, 2017·Frontiers in Immunology·Irma TindemansRudi W Hendriks
Apr 4, 2019·Journal for Immunotherapy of Cancer·Elena E TcheknevaMikhail M Dikov
May 6, 2019·International Journal of Molecular Sciences·Sunil KumarYong-Soo Bae
Mar 3, 2010·Immunological Reviews·Pingyan ChengDmitry Gabrilovich
Aug 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoo Seob ShinErwin W Gelfand
Feb 6, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susan EdwardsMark Biffen
Aug 31, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin FelicesJeffrey S Miller
May 2, 2012·Breast Cancer Research and Treatment·Bisrat G DebebWendy A Woodward

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