PMID: 8996627Nov 1, 1996Paper

Suppression of the degradation of adenine nucleotides during ischemia may not be a sufficient mechanism for infarct size limitation by preconditioning

Basic Research in Cardiology
T MiuraO Iimura

Abstract

Preconditioning is known to decelerate degradation of the tissue adenine nucleotides during ischemia and to delay ischemic myocardial necrosis. However, it is not known whether these two phenomena are related. To obtain an insight into this question, the present study examined whether adenosine and B2 receptor antagonists, which block the infarct size-limiting effect of preconditioning, modify the interstitial purine levels during preconditioning and subsequent sustained ischemia. In pentobarbital anesthetized open-chest rabbits, a microdialysis probe was placed in the territory of a branch of the left coronary artery, and perfused with Ringer solution. Preconditioning was performed with 5 min ischemia/5 min reperfusion. Dialysate adenosine and inosine were elevated from the baseline values of 0.064 +/- 0.011 and 0.329 +/- 0.044 microM to 0.189 +/- 0.069 and 4.106 +/- 1.451 microM, respectively during preconditioning, but their elevation during a subsequent 20 min of ischemia was significantly lower compared with that in the non-preconditioned myocardium. This suppression of the purine accumulation during ischemia by preconditioning was not abolished by 2 micrograms/kg of Hoe 140, a specific B2 receptor antagonist, or by 10 mg/...Continue Reading

References

Mar 1, 1991·British Journal of Pharmacology·K WirthJ Knolle
Jul 1, 1992·The Histochemical Journal·M Borgers, F Thoné
Dec 1, 1991·Journal of Molecular and Cellular Cardiology·R B JenningsK A Reimer
Jan 1, 1987·Journal of Cardiovascular Pharmacology·W Linz, B A Schölkens
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Citations

May 28, 2010·Cardiovascular Drugs and Therapy·Xiulan YangJames M Downey
May 26, 2005·Journal of Molecular and Cellular Cardiology·Andreas SkyschallyGerd Heusch
Jul 16, 2003·Clinical and Experimental Pharmacology & Physiology·Eleni VasaraAntigone Lazou
Sep 11, 2001·Journal of Molecular and Cellular Cardiology·R B JenningsK A Reimer
Mar 5, 1999·Clinical and Experimental Pharmacology & Physiology·T Miura, A Tsuchida
Sep 24, 1998·The American Journal of Physiology·T MikiK Shimamoto
May 18, 1999·The American Journal of Physiology·S KitamuraA G Scicli

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